M. E. Suzanne Lewis, MD, FRCPC, FCCMG

Clinical Professor Department of Medical Genetics, University of British Columbia Children's and Women's Health Centre of BC Email:

• Lab web page

Research Interests: Genetic, genomic and comprehensive phenotyping studies for the autism spectrum disorders, idiopathic intellectual disabilities and other complex disorders of neurodevelopmental and/or behavioral disability. Clinical genetic, neurodevelopmental and behavioural phenotype analysis, clinical and applied genotype/phenotype correlations, somatic gene transfer and therapy.

Selected Publications:
Lewis MES. The complicity of segmental duplicity in human genomic disease (2003). Clin Genetics: 63:262-267.

Lewis MES. Dissecting the genetic bases of brain form, function and phenotype (2002). Clin. Genetics 62(2):104-109.

Strømme P, Mangelsdorf ME, Shaw MA, Lower KM, Lewis MES, Bruyere H, Lütcherath V, Gedeon AK, Wallace RH, Scheffer IE, Turner G, Partington M, Frints S, Fryns J-P, Sutherland GR, Mulley JC and Gécz J. Mutations of the human ortholog of Aristaless cause X-linked mental retardation and epilepsy (2002). Nature Genetics 30(4):441-445.

Lewis, MES. Refining the spectrum of genes in autism spectrum disorder (2002). Clin. Genetics 61(1):7-13.

Lewis, MES. Gene expression and therapy in lipoprotein disease models - Getting to the heart of the matter (2001). Clin. Genet 59(6):587- 592.

Lewis MES. Real facts from artificial chromosomes (2001). Clin. Genetics: 59(1):12-16.

Penaherrera MS, Barrett IJ, Brown CJ, Langlois S, Yong S-L, Lewis MES, Bruyere H, Howard-Peebles P, Kalousek DK and Robinson WP. An association between skewed X-chromosome inactivation in diploid fetal tissues and abnormal outcome in mosaic trisomies predominantly confined to the placenta (2000). Clin. Genetics: 58(6):436-446.

Lewis MES. Altering the Pathway To Human Gene Therapy (2000). Clin. Genetics: 58(1):12-15. Bruyere H, Wood S, MacLeod PJ, Langlois S and Lewis MES (2000). A new X-linked mental retardation/epilepsy gene localized to Xp21.3-Xp22.1 (West Syndrome). Excerpta Medica: Search on Epilepsy: 7(2):21-23.

Lewis MES. "New Age" Gene Medicines for the 21st Century (2000). Clin. Genetics: 57:11-15.