Robert J. Kay, PhD
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Professor Department of Medical Genetics, University of British Columbia Senior Scientist, Terry Fox Laboratory Terry Fox Cancer Research Scientist of the NCI Tel: 604-675-8134 Fax: 604-877-0712 Email:  |
Selected Publication:
Beaulieu N, Zahedi B, Goulding RE, Tazmini G, Anthony KV, Omeis SL, de Jong DR, & Kay RJ. Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane. Mol Biol Cell 18 (8): 3156-68, 2007.
Johnson JE, Goulding RE, Ding Z, Partovi A, Anthony KV, Beaulieu N, Tazmini G, Cornell RB, & Kay RJ. Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs. Biochem J 406 (2): 223-36, 2007.
Klinger MB, Guilbault B, Goulding RE, & Kay RJ. Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors. Oncogene 24 (16): 2695-704, 2005.
Klinger MB, Guilbault B, & Kay RJ. The RhoA- and CDC42-specific exchange factor Dbs promotes expansion of immature thymocytes and deletion of double-positive and single-positive thymocytes. Eur J Immunol 34 (3): 806-16, 2004.
Guilbault B, & Kay RJ. RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis. J Biol Chem 279 (19): 19523-30, 2004.
Norment AM, Bogatzki LY, Klinger M, Ojala EW, Bevan MJ, & Kay RJ. Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes. J Immunol 170 (3): 1141-9, 2003.