Michael R. Hayden, MB, ChB, PhD, FRCP(C), FRSC
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University Killam Professor Department of Medical Genetics, University of British Columbia Director and Senior Scientist, Centre for Molecular Medicine and Therapeutics Tel: +1 (604) 875-3535 Fax: +1 (604) 875-3819 Email:  |
Selected Publications:
Xian X, Liu T, Yu J, Wang Y, Miao Y, Zhang J, Yu Y, Ross C, Karasinska JM, Hayden MR, Liu G, Chui D. Presynaptic defects underlying impaired learning and memory function in lipoprotein lipase-deficient mice. J. Neurosci. 29(14):4681-5. (2009) PMID 19357293
Huang K, Sanders S, Singaraja R, Orban P, Cijsouw T, Arstikaitis P, Yanai A, Hayden MR, El-Husseini A. Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity. FASEB J. (2009) PMID 19299482
Karasinska JM, Rinninger F, Lütjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR. Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J. Neurosci. 29(11):3579-89. (2009) PMID 19295162
Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease. J. Neurosci. 29(8):2414-27. (2009) PMID 19244517
Pouladi MA, Graham RK, Karasinska JM, Xie Y, Santos RD, Petersén A, Hayden MR. Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin. Brain 132(Pt 4):919-32. (2009) PMID 19224899
Ratovitski T, Gucek M, Jiang H, Chighladze E, Waldron E, D'Ambola J, Hou Z, Liang Y, Poirier MA, Hirschhorn RR, Graham R, Hayden MR, Cole RN, Ross CA. Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells. J. Biol. Chem. 284(16):10855-67. (2009) PMID 19204007
Guo H, Ma Y, Zhang B, Sun B, Niu R, Ying G, Zhang N. Pivotal Advance: PKC{zeta} is required for migration of macrophages. J. Leukoc. Biol. (2009) PMID 19201988
Brunham LR, Singaraja RR, Duong M, Timmins JM, Fievet C, Bissada N, Kang MH, Samra A, Fruchart JC, McManus B, Staels B, Parks JS, Hayden MR. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 29(4):548-54. (2009) PMID 19201688
Vaessen SF, Dallinga-Thie GM, Ross CJ, Splint LJ, Castellani LW, Rensen PC, Hayden MR, Schaap FG, Kuivenhoven JA. Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels. J. Lipid Res. 50(5):880-4. (2009) PMID 19141870
MacDonald ML, van Eck M, Hildebrand RB, Wong BW, Bissada N, Ruddle P, Kontush A, Hussein H, Pouladi MA, Chapman MJ, Fievet C, van Berkel TJ, Staels B, McManus BM, Hayden MR. Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 29(3):341-7. (2009) PMID 19095997
Bartha I, Dinya T, Seres I, Paragh G, Ross C, Hayden MR, Biró S, Vargha G. Acute hypertriglyceridemic pancreatitis during pregnancy due to homozygous lipoprotein lipase gene mutation. Clin. Chim. Acta 400(1-2):137-8. (2009) PMID 19000906
Yang F, Wang Y, Sternfeld L, Rodriguez JA, Ross C, Hayden MR, Carriere F, Liu G, Schulz I. The role of free fatty acids, pancreatic lipase and Ca+ signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice. 195(1):13-28. (2009) PMID 18983441
Madadi P, Ross CJ, Hayden MR, Carleton BC, Gaedigk A, Leeder JS, Koren G. Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin. Pharmacol. Ther. 85(1):31-5. (2009) PMID 18719619
Cowan CM, Fan MM, Fan J, Shehadeh J, Zhang LY, Graham RK, Hayden MR, Raymond LA. Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity. J. Neurosci. 28(48):12725-35. (2008) PMID 19036965
Warby SC, Doty CN, Graham RK, Shively J, Singaraja RR, Hayden MR. Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments. Mol. Cell. Neurosci. (2008) PMID 18992820
Brunham LR, Kastelein JJ, Hayden MR. ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease. JAMA 300(17):1997-8; author reply 1998. (2008) PMID 18984885
Wang Y, Sternfeld L, Yang F, Rodriguez JA, Ross C, Hayden MR, Carriere F, Liu G, Hofer W, Schulz I. Enhanced susceptibility to pancreatitis in severe hypertriglyceridemic lipoprotein lipase deficient mice and agonist-like function of pancreatic lipase in pancreatic cells. Gut (2008) PMID 18936103
Stroes ES, Nierman MC, Meulenberg JJ, Franssen R, Twisk J, Henny CP, Maas MM, Zwinderman AH, Ross C, Aronica E, High KA, Levi MM, Hayden MR, Kastelein JJ, Kuivenhoven JA. Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients. Arterioscler. Thromb. Vasc. Biol. 28(12):2303-4. (2008) PMID 18802015
Björkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, Raibon E, Lee RV, Benn CL, Soulet D, Magnusson A, Woodman B, Landles C, Pouladi MA, Hayden MR, Khalili-Shirazi A, Lowdell MW, Brundin P, Bates GP, Leavitt BR, Möller T, Tabrizi SJ. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J. Exp. Med. 205(8):1869-77. (2008) PMID 18625748
Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum. Mol. Genet. 17(17):2738-51. (2008) PMID 18558632
Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I. Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease. Neurobiol. Dis. 31(1):80-8. (2008) PMID 18502655
Warby SC, Doty CN, Graham RK, Carroll JB, Yang YZ, Singaraja RR, Overall CM, Hayden MR. Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus. Hum. Mol. Genet. 17(15):2390-404. (2008) PMID 18445618
Lerch JP, Carroll JB, Dorr A, Spring S, Evans AC, Hayden MR, Sled JG, Henkelman RM. Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease. Neuroimage 41(2):243-51. (2008) PMID 18387826
Brunham LR, Kruit JK, Verchere CB, Hayden MR. Cholesterol in islet dysfunction and type 2 diabetes. J. Clin. Invest. 118(2):403-8. (2008) PMID 18246189
Zhang X, Qi R, Xian X, Yang F, Blackstein M, Deng X, Fan J, Ross C, Karasinska J, Hayden MR, Liu G. Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet. Circ. Res. 102(2):250-6. (2008) PMID 18032735
Fan MM, Zhang H, Hayden MR, Pelech SL, Raymond LA. Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors. J. Neurochem. 104(3):790-805. (2008) PMID 17971125
MacDonald ML, Singaraja RR, Bissada N, Ruddle P, Watts R, Karasinska JM, Gibson WT, Fievet C, Vance JE, Staels B, Hayden MR. Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. J. Lipid Res. 49(1):217-29. (2008) PMID 17960025
Bombard Y, Penziner E, Suchowersky O, Guttman M, Paulsen JS, Bottorff JL, Hayden MR. Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease. Eur. J. Hum. Genet. 16(3):279-89. (2008) PMID 17957229
Penziner E, Williams JK, Erwin C, Bombard Y, Wallis A, Beglinger LJ, Hayden MR, Paulsen JS. Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147(3):320-5. (2008) PMID 17948904
Lerch JP, Carroll JB, Spring S, Bertram LN, Schwab C, Hayden MR, Henkelman RM. Automated deformation analysis in the YAC128 Huntington disease mouse model. Neuroimage 39(1):32-9. (2008) PMID 17942324
Ratovitski T, Nakamura M, D'Ambola J, Chighladze E, Liang Y, Wang W, Graham R, Hayden MR, Borchelt DR, Hirschhorn RR, Ross CA. N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease. Cell Cycle 6(23):2970-81. (2007) PMID 18156806
Fernandes HB, Baimbridge KG, Church J, Hayden MR, Raymond LA. Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease. J. Neurosci. 27(50):13614-23. (2007) PMID 18077673
Parker JA, Metzler M, Georgiou J, Mage M, Roder JC, Rose AM, Hayden MR, Néri C. Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity. J. Neurosci. 27(41):11056-64. (2007) PMID 17928447
Gibson WT, Hayden MR. Mycophenolate mofetil and atherosclerosis: results of animal and human studies. Ann. N. Y. Acad. Sci. 1110:209-21. (2007) PMID 17911436
Ross CJ, Carleton B, Warn DG, Stenton SB, Rassekh SR, Hayden MR. Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children. Ann. N. Y. Acad. Sci. 1110:177-92. (2007) PMID 17911433
Valenza M, Carroll JB, Leoni V, Bertram LN, Björkhem I, Singaraja RR, Di Donato S, Lutjohann D, Hayden MR, Cattaneo E. Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation. Hum. Mol. Genet. 16(18):2187-98. (2007) PMID 17613541
Johnson SA, Stout JC, Solomon AC, Langbehn DR, Aylward EH, Cruce CB, Ross CA, Nance M, Kayson E, Julian-Baros E, Hayden MR, Kieburtz K, Guttman M, Oakes D, Shoulson I, Beglinger L, Duff K, Penziner E, Paulsen JS, . Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease. Brain 130(Pt 7):1732-44. (2007) PMID 17584778
Benn CL, Slow EJ, Farrell LA, Graham R, Deng Y, Hayden MR, Cha JH. Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease. Neuroscience 147(2):354-72. (2007) PMID 17544587
Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Hum. Mol. Genet. 16(15):1845-61. (2007) PMID 17519223
Butland SL, Devon RS, Huang Y, Mead CL, Meynert AM, Neal SJ, Lee SS, Wilkinson A, Yang GS, Yuen MM, Hayden MR, Holt RA, Leavitt BR, Ouellette BF. CAG-encoded polyglutamine length polymorphism in the human genome. BMC Genomics 8:126. (2007) PMID 17519034
Goldberg YP, MacFarlane J, MacDonald ML, Thompson J, Dube MP, Mattice M, Fraser R, Young C, Hossain S, Pape T, Payne B, Radomski C, Donaldson G, Ives E, Cox J, Younghusband HB, Green R, Duff A, Boltshauser E, Grinspan GA, Dimon JH, Sibley BG, Andria G, Toscano E, Kerdraon J, Bowsher D, Pimstone SN, Samuels ME, Sherrington R, Hayden MR. Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin. Genet. 71(4):311-9. (2007) PMID 17470132
Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y. When good drugs go bad. Nature 446(7139):975-7. (2007) PMID 17460642
Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersén A, Björkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR. Testicular degeneration in Huntington disease. Neurobiol. Dis. 26(3):512-20. (2007) PMID 17433700
Fan MM, Fernandes HB, Zhang LY, Hayden MR, Raymond LA. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. J. Neurosci. 27(14):3768-79. (2007) PMID 17409241
Van Raamsdonk JM, Warby SC, Hayden MR. Selective degeneration in YAC mouse models of Huntington disease. Brain Res. Bull. 72(2-3):124-31. (2007) PMID 17352936
Metzler M, Gan L, Wong TP, Liu L, Helm J, Liu L, Georgiou J, Wang Y, Bissada N, Cheng K, Roder JC, Wang YT, Hayden MR. NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1. J. Neurosci. 27(9):2298-308. (2007) PMID 17329427
Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat. Med. 13(3):340-7. (2007) PMID 17322896
Bombard Y, Penziner E, Decolongon J, Klimek ML, Creighton S, Suchowersky O, Guttman M, Paulsen JS, Bottorff JL, Hayden MR. Managing genetic discrimination: strategies used by individuals found to have the Huntington disease mutation. Clin. Genet. 71(3):220-31. (2007) PMID 17309644
Solomon AC, Stout JC, Johnson SA, Langbehn DR, Aylward EH, Brandt J, Ross CA, Beglinger L, Hayden MR, Kieburtz K, Kayson E, Julian-Baros E, Duff K, Guttman M, Nance M, Oakes D, Shoulson I, Penziner E, Paulsen JS, . Verbal episodic memory declines prior to diagnosis in Huntington's disease. 45(8):1767-76. (2007) PMID 17303196
Van Raamsdonk JM, Metzler M, Slow E, Pearson J, Schwab C, Carroll J, Graham RK, Leavitt BR, Hayden MR. Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain. Neurobiol. Dis. 26(1):189-200. (2007) PMID 17276692
Hirsch-Reinshagen V, Chan JY, Wilkinson A, Tanaka T, Fan J, Ou G, Maia LF, Singaraja RR, Hayden MR, Wellington CL. Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. J. Lipid Res. 48(4):914-23. (2007) PMID 17235115
Wang J, Xian X, Huang W, Chen L, Wu L, Zhu Y, Fan J, Ross C, Hayden MR, Liu G. Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 27(1):197-203. (2007) PMID 17038632
Khatchadourian K, Smith CE, Metzler M, Gregory M, Hayden MR, Cyr DG, Hermo L. Structural abnormalities in spermatids together with reduced sperm counts and motility underlie the reproductive defect in HIP1-/- mice. Mol. Reprod. Dev. 74(3):341-59. (2007) PMID 16967501
Van Raamsdonk JM, Pearson J, Murphy Z, Hayden MR, Leavitt BR. Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease. 7:80. (2006) PMID 17147801
Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM. Huntingtin inhibits caspase-3 activation. EMBO J. 25(24):5896-906. (2006) PMID 17124493
Oliveira JM, Chen S, Almeida S, Riley R, Gonçalves J, Oliveira CR, Hayden MR, Nicholls DG, Ellerby LM, Rego AC. Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. J. Neurosci. 26(43):11174-86. (2006) PMID 17065457
Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW. Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev. Biol. 300(2):523-33. (2006) PMID 17027958
Leavitt BR, Hayden MR. Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease? 2(10):536-7. (2006) PMID 16990826
Semaka A, Creighton S, Warby S, Hayden MR. Predictive testing for Huntington disease: interpretation and significance of intermediate alleles. Clin. Genet. 70(4):283-94. (2006) PMID 16965319
Kishikawa S, Li JL, Gillis T, Hakky MM, Warby S, Hayden M, MacDonald ME, Myers RH, Gusella JF. Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Neurobiol. Dis. 24(2):280-5. (2006) PMID 16962786
Brunham LR, Kruit JK, Pape TD, Parks JS, Kuipers F, Hayden MR. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ. Res. 99(7):672-4. (2006) PMID 16946132
Singaraja RR, Van Eck M, Bissada N, Zimetti F, Collins HL, Hildebrand RB, Hayden A, Brunham LR, Kang MH, Fruchart JC, Van Berkel TJ, Parks JS, Staels B, Rothblat GH, Fiévet C, Hayden MR. Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circulation 114(12):1301-9. (2006) PMID 16940190
Li JL, Hayden MR, Warby SC, Durr A, Morrison PJ, Nance M, Ross CA, Margolis RL, Rosenblatt A, Squitieri F, Frati L, Gómez-Tortosa E, García CA, Suchowersky O, Klimek ML, Trent RJ, McCusker E, Novelletto A, Frontali M, Paulsen JS, Jones R, Ashizawa T, Lazzarini A, Wheeler VC, Prakash R, Xu G, Djoussé L, Mysore JS, Gillis T, Hakky M, Cupples LA, Saint-Hilaire MH, Cha JH, Hersch SM, Penney JB, Harrison MB, Perlman SL, Zanko A, Abramson RK, Lechich AJ, Duckett A, Marder K, Conneally PM, Gusella JF, MacDonald ME, Myers RH. Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med. Genet. 7:71. (2006) PMID 16914060
Burgess BL, McIsaac SA, Naus KE, Chan JY, Tansley GH, Yang J, Miao F, Ross CJ, van Eck M, Hayden MR, van Nostrand W, St George-Hyslop P, Westaway D, Wellington CL. Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol. Dis. 24(1):114-27. (2006) PMID 16899370
Alvarez C, Tredwell S, De Vera M, Hayden M. The genotype-phenotype correlation of hereditary multiple exostoses. Clin. Genet. 70(2):122-30. (2006) PMID 16879194
Singaraja RR, Visscher H, James ER, Chroni A, Coutinho JM, Brunham LR, Kang MH, Zannis VI, Chimini G, Hayden MR. Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro. Circ. Res. 99(4):389-97. (2006) PMID 16873719
Björkqvist M, Petersén A, Nielsen J, Ecker D, Mulder H, Hayden MR, Landwehrmeyer B, Brundin P, Leavitt BR. Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease. Clin. Genet. 70(1):78-9. (2006) PMID 16813610
Slow EJ, Graham RK, Hayden MR. To be or not to be toxic: aggregations in Huntington and Alzheimer disease. Trends Genet. 22(8):408-11. (2006) PMID 16806565
Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 125(6):1179-91. (2006) PMID 16777606
Devon RS, Orban PC, Gerrow K, Barbieri MA, Schwab C, Cao LP, Helm JR, Bissada N, Cruz-Aguado R, Davidson TL, Witmer J, Metzler M, Lam CK, Tetzlaff W, Simpson EM, McCaffery JM, El-Husseini AE, Leavitt BR, Hayden MR. Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc. Natl. Acad. Sci. U.S.A. 103(25):9595-600. (2006) PMID 16769894
Paulsen JS, Hayden M, Stout JC, Langbehn DR, Aylward E, Ross CA, Guttman M, Nance M, Kieburtz K, Oakes D, Shoulson I, Kayson E, Johnson S, Penziner E, . Preparing for preventive clinical trials: the Predict-HD study. Arch. Neurol. 63(6):883-90. (2006) PMID 16769871
Ross CJ, Twisk J, Bakker AC, Miao F, Verbart D, Rip J, Godbey T, Dijkhuizen P, Hermens WT, Kastelein JJ, Kuivenhoven JA, Meulenberg JM, Hayden MR. Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation. Hum. Gene Ther. 17(5):487-99. (2006) PMID 16716106
Brunham LR, Singaraja RR, Hayden MR. Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis. Annu. Rev. Nutr. 26:105-29. (2006) PMID 16704350
Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR. Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat. Neurosci. 9(6):824-31. (2006) PMID 16699508
Guidetti P, Bates GP, Graham RK, Hayden MR, Leavitt BR, MacDonald ME, Slow EJ, Wheeler VC, Woodman B, Schwarcz R. Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Neurobiol. Dis. 23(1):190-7. (2006) PMID 16697652
Rip J, Nierman MC, Ross CJ, Jukema JW, Hayden MR, Kastelein JJ, Stroes ES, Kuivenhoven JA. Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation. Arterioscler. Thromb. Vasc. Biol. 26(6):1236-45. (2006) PMID 16574898
Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR. Body weight is modulated by levels of full-length huntingtin. Hum. Mol. Genet. 15(9):1513-23. (2006) PMID 16571604
Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J. Clin. Invest. 116(4):1052-62. (2006) PMID 16543947
Bae BI, Hara MR, Cascio MB, Wellington CL, Hayden MR, Ross CA, Ha HC, Li XJ, Snyder SH, Sawa A. Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proc. Natl. Acad. Sci. U.S.A. 103(9):3405-9. (2006) PMID 16492755
Hegele RA. Gene therapy with lipoprotein lipase variant S447X. Arterioscler. Thromb. Vasc. Biol. 26(3):e25; author reply e25-8. (2006) PMID 16484602
Zhao T, Guo J, Li H, Huang W, Xian X, Ross CJ, Hayden MR, Wen Z, Liu G. Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia. Biochem. Biophys. Res. Commun. 341(4):1066-71. (2006) PMID 16460682
Van Eck M, Singaraja RR, Ye D, Hildebrand RB, James ER, Hayden MR, Van Berkel TJ. Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. Arterioscler. Thromb. Vasc. Biol. 26(4):929-34. (2006) PMID 16456089
Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR. Wild-type huntingtin protects neurons from excitotoxicity. J. Neurochem. 96(4):1121-9. (2006) PMID 16417581
Warby S, MacDonald M, Hayden M, Butland S, Ouellette F. FASA-57 cDNA shares no homology with coding sequence of HD gene. J. Reprod. Immunol. 69(1):9-10; author reply 11. (2006) PMID 16386309
van Leuven SI, Kastelein JJ, Allison AC, Hayden MR, Stroes ES. Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles? Cardiovasc. Res. 69(2):341-7. (2006) PMID 16289002
Graham RK, Slow EJ, Deng Y, Bissada N, Lu G, Pearson J, Shehadeh J, Leavitt BR, Raymond LA, Hayden MR. Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models. Neurobiol. Dis. 21(2):444-55. (2006) PMID 16230019
Shehadeh J, Fernandes HB, Zeron Mullins MM, Graham RK, Leavitt BR, Hayden MR, Raymond LA. Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiol. Dis. 21(2):392-403. (2006) PMID 16165367
Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. PLoS Genet. 1(6):e83. (2005) PMID 16429166
Hayden MR, Bombard Y. Psychosocial effects of predictive testing for Huntington's disease. 96:226-39. (2005) PMID 16383222
Van Raamsdonk JM, Murphy Z, Slow EJ, Leavitt BR, Hayden MR. Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 14(24):3823-35. (2005) PMID 16278236
Rip J, Nierman MC, Sierts JA, Petersen W, Van den Oever K, Van Raalte D, Ross CJ, Hayden MR, Bakker AC, Dijkhuizen P, Hermens WT, Twisk J, Stroes E, Kastelein JJ, Kuivenhoven JA, Meulenberg JM. Gene therapy for lipoprotein lipase deficiency: working toward clinical application. Hum. Gene Ther. 16(11):1276-86. (2005) PMID 16259561
Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR. Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. J. Neurochem. 95(1):210-20. (2005) PMID 16181425
van Leuven SI, Kastelein JJ, Hayden MR, d'Cruz D, Hughes GR, Stroes ES. Cardiovascular disease in systemic lupus erythematosus: has the time for action come? Curr. Opin. Lipidol. 16(5):501-6. (2005) PMID 16148533
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Singaraja RR, James ER, Crim J, Visscher H, Chatterjee A, Hayden MR. Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1. J. Lipid Res. 46(10):2061-71. (2005) PMID 16024915
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Timmins JM, Lee JY, Boudyguina E, Kluckman KD, Brunham LR, Mulya A, Gebre AK, Coutinho JM, Colvin PL, Smith TL, Hayden MR, Maeda N, Parks JS. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J. Clin. Invest. 115(5):1333-42. (2005) PMID 15841208
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Margolis RL, Holmes SE, Rosenblatt A, Gourley L, O'Hearn E, Ross CA, Seltzer WK, Walker RH, Ashizawa T, Rasmussen A, Hayden M, Almqvist EW, Harris J, Fahn S, MacDonald ME, Mysore J, Shimohata T, Tsuji S, Potter N, Nakaso K, Adachi Y, Nakashima K, Bird T, Krause A, Greenstein P. Huntington's Disease-like 2 (HDL2) in North America and Japan. Ann. Neurol. 56(5):670-4. (2004) PMID 15468075
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Bezprozvanny I, Hayden MR. Deranged neuronal calcium signaling and Huntington disease. Biochem. Biophys. Res. Commun. 322(4):1310-7. (2004) PMID 15336977
Hirsch-Reinshagen V, Zhou S, Burgess BL, Bernier L, McIsaac SA, Chan JY, Tansley GH, Cohn JS, Hayden MR, Wellington CL. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J. Biol. Chem. 279(39):41197-207. (2004) PMID 15269218
Li L, Murphy TH, Hayden MR, Raymond LA. Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease. J. Neurophysiol. 92(5):2738-46. (2004) PMID 15240759
Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429(6987):75-9. (2004) PMID 15129283
Delatycki MB, Allen KJ, Gow P, MacFarlane J, Radomski C, Thompson J, Hayden MR, Goldberg YP, Samuels ME. A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis. Clin. Genet. 65(5):378-83. (2004) PMID 15099344
Lafreniere RG, MacDonald ML, Dube MP, MacFarlane J, O'Driscoll M, Brais B, Meilleur S, Brinkman RR, Dadivas O, Pape T, Platon C, Radomski C, Risler J, Thompson J, Guerra-Escobio AM, Davar G, Breakefield XO, Pimstone SN, Green R, Pryse-Phillips W, Goldberg YP, Younghusband HB, Hayden MR, Sherrington R, Rouleau GA, Samuels ME, . Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates. Am. J. Hum. Genet. 74(5):1064-73. (2004) PMID 15060842
Harper PS, Gevers S, de Wert G, Creighton S, Bombard Y, Hayden MR. Genetic testing and Huntington's disease: issues of employment. 3(4):249-52. (2004) PMID 15039038
Zeron MM, Fernandes HB, Krebs C, Shehadeh J, Wellington CL, Leavitt BR, Baimbridge KG, Hayden MR, Raymond LA. Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease. Mol. Cell. Neurosci. 25(3):469-79. (2004) PMID 15033175
Djoussé L, Knowlton B, Hayden MR, Almqvist EW, Brinkman RR, Ross CA, Margolis RL, Rosenblatt A, Durr A, Dode C, Morrison PJ, Novelletto A, Frontali M, Trent RJ, McCusker E, Gómez-Tortosa E, Mayo Cabrero D, Jones R, Zanko A, Nance M, Abramson RK, Suchowersky O, Paulsen JS, Harrison MB, Yang Q, Cupples LA, Mysore J, Gusella JF, MacDonald ME, Myers RH. Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16. Neurogenetics 5(2):109-14. (2004) PMID 15029481
Selva DM, Hirsch-Reinshagen V, Burgess B, Zhou S, Chan J, McIsaac S, Hayden MR, Hammond GL, Vogl AW, Wellington CL. The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility. J. Lipid Res. 45(6):1040-50. (2004) PMID 15026428
Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR, . A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin. Genet. 65(4):267-77. (2004) PMID 15025718
Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. J. Biol. Chem. 279(19):20211-20. (2004) PMID 14981075
Hovingh GK, Kuivenhoven JA, Bisoendial RJ, Groen AK, van Dam M, van Tol A, Wellington C, Hayden MR, Smelt AH, Kastelein JJ. HDL deficiency and atherosclerosis: lessons from Tangier disease. J. Intern. Med. 255(2):299-301. (2004) PMID 14746569
Qin ZH, Wang Y, Sapp E, Cuiffo B, Wanker E, Hayden MR, Kegel KB, Aronin N, DiFiglia M. Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. J. Neurosci. 24(1):269-81. (2004) PMID 14715959
Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ. 11(4):424-38. (2004) PMID 14713958
Zala D, Bensadoun JC, Pereira de Almeida L, Leavitt BR, Gutekunst CA, Aebischer P, Hayden MR, Déglon N. Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice. Exp. Neurol. 185(1):26-35. (2004) PMID 14697316
Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dubé MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 36(1):77-82. (2004) PMID 14647275
Hand CK, Devon RS, Gros-Louis F, Rochefort D, Khoris J, Meininger V, Bouchard JP, Camu W, Hayden MR, Rouleau GA. Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis. Arch. Neurol. 60(12):1768-71. (2003) PMID 14676054
Kuivenhoven JA, Hovingh GK, van Tol A, Jauhiainen M, Ehnholm C, Fruchart JC, Brinton EA, Otvos JD, Smelt AH, Brownlee A, Zwinderman AH, Hayden MR, Kastelein JJ. Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size. Atherosclerosis 171(2):311-9. (2003) PMID 14644402
Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA. Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiol. Aging 24(8):1113-21. (2003) PMID 14643383
Aylward EH, Rosenblatt A, Field K, Yallapragada V, Kieburtz K, McDermott M, Raymond LA, Almqvist EW, Hayden M, Ross CA. Caudate volume as an outcome measure in clinical trials for Huntington's disease: a pilot study. Brain Res. Bull. 62(2):137-41. (2003) PMID 14638387
Brunham LR, Hayden MR. Clarity is essential when using nucleotide number systems. Atherosclerosis 170(2):349. (2003) PMID 14612218
Almqvist EW, Brinkman RR, Wiggins S, Hayden MR, . Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington's disease. Clin. Genet. 64(4):300-9. (2003) PMID 12974735
Zhang Y, Li M, Drozda M, Chen M, Ren S, Mejia Sanchez RO, Leavitt BR, Cattaneo E, Ferrante RJ, Hayden MR, Friedlander RM. Depletion of wild-type huntingtin in mouse models of neurologic diseases. J. Neurochem. 87(1):101-6. (2003) PMID 12969257
Hoogendijk CF, Scholtz CL, Pimstone SM, Ehrenborg E, Kastelein JJ, Defesche JC, Thiart R, du Plessis L, de Villiers JN, Zaahl MG, Delport R, Rubinsztein DC, Raffel LJ, Grim CE, Mediene-Benchekor S, Amouyel P, Brousseau T, Steyn K, Lombard CJ, Hayden MR, Kotze MJ. Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element. Mol. Cell. Probes 17(4):175-81. (2003) PMID 12944120
Devon RS, Helm JR, Rouleau GA, Leitner Y, Lerman-Sagie T, Lev D, Hayden MR. The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings. Clin. Genet. 64(3):210-5. (2003) PMID 12919135
McCrindle BW, Ose L, Marais AD. Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial. J. Pediatr. 143(1):74-80. (2003) PMID 12915827
Li JL, Hayden MR, Almqvist EW, Brinkman RR, Durr A, Dodé C, Morrison PJ, Suchowersky O, Ross CA, Margolis RL, Rosenblatt A, Gómez-Tortosa E, Cabrero DM, Novelletto A, Frontali M, Nance M, Trent RJ, McCusker E, Jones R, Paulsen JS, Harrison M, Zanko A, Abramson RK, Russ AL, Knowlton B, Djoussé L, Mysore JS, Tariot S, Gusella MF, Wheeler VC, Atwood LD, Cupples LA, Saint-Hilaire M, Cha JH, Hersch SM, Koroshetz WJ, Gusella JF, MacDonald ME, Myers RH. A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. Am. J. Hum. Genet. 73(3):682-7. (2003) PMID 12900792
Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, Rigamonti D, Cattaneo E. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat. Genet. 35(1):76-83. (2003) PMID 12881722
Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I. Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39(2):227-39. (2003) PMID 12873381
Hayden MR. Predictive testing for Huntington's disease: a universal model? 2(3):141-2. (2003) PMID 12849232
Metzler M, Li B, Gan L, Georgiou J, Gutekunst CA, Wang Y, Torre E, Devon RS, Oh R, Legendre-Guillemin V, Rich M, Alvarez C, Gertsenstein M, McPherson PS, Nagy A, Wang YT, Roder JC, Raymond LA, Hayden MR. Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. EMBO J. 22(13):3254-66. (2003) PMID 12839988
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 12(13):1555-67. (2003) PMID 12812983
Creighton S, Almqvist EW, MacGregor D, Fernandez B, Hogg H, Beis J, Welch JP, Riddell C, Lokkesmoe R, Khalifa M, MacKenzie J, Sajoo A, Farrell S, Robert F, Shugar A, Summers A, Meschino W, Allingham-Hawkins D, Chiu T, Hunter A, Allanson J, Hare H, Schween J, Collins L, Sanders S, Greenberg C, Cardwell S, Lemire E, MacLeod P, Hayden MR. Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000. Clin. Genet. 63(6):462-75. (2003) PMID 12786753
Djoussé L, Knowlton B, Hayden M, Almqvist EW, Brinkman R, Ross C, Margolis R, Rosenblatt A, Durr A, Dode C, Morrison PJ, Novelletto A, Frontali M, Trent RJ, McCusker E, Gómez-Tortosa E, Mayo D, Jones R, Zanko A, Nance M, Abramson R, Suchowersky O, Paulsen J, Harrison M, Yang Q, Cupples LA, Gusella JF, MacDonald ME, Myers RH. Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. Am. J. Med. Genet. A 119A(3):279-82. (2003) PMID 12784292
Bisoendial RJ, Hovingh GK, Levels JH, Lerch PG, Andresen I, Hayden MR, Kastelein JJ, Stroes ES. Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein. Circulation 107(23):2944-8. (2003) PMID 12771001
Singaraja RR, Brunham LR, Visscher H, Kastelein JJ, Hayden MR. Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene. Arterioscler. Thromb. Vasc. Biol. 23(8):1322-32. (2003) PMID 12763760
Hussain NK, Yamabhai M, Bhakar AL, Metzler M, Ferguson SS, Hayden MR, McPherson PS, Kay BK. A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding. J. Biol. Chem. 278(31):28823-30. (2003) PMID 12750376
Wellington CL, Brunham LR, Zhou S, Singaraja RR, Visscher H, Gelfer A, Ross C, James E, Liu G, Huber MT, Yang YZ, Parks RJ, Groen A, Fruchart-Najib J, Hayden MR. Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1. J. Lipid Res. 44(8):1470-80. (2003) PMID 12730295
Hovingh GK, Van Wijland MJ, Brownlie A, Bisoendial RJ, Hayden MR, Kastelein JJ, Groen AK. The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia. J. Lipid Res. 44(6):1251-5. (2003) PMID 12700344
Squitieri F, Gellera C, Cannella M, Mariotti C, Cislaghi G, Rubinsztein DC, Almqvist EW, Turner D, Bachoud-Lévi AC, Simpson SA, Delatycki M, Maglione V, Hayden MR, Donato SD. Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course. Brain 126(Pt 4):946-55. (2003) PMID 12615650
Mulligan JD, Flowers MT, Tebon A, Bitgood JJ, Wellington C, Hayden MR, Attie AD. ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens. J. Biol. Chem. 278(15):13356-66. (2003) PMID 12551945
Gros-Louis F, Meijer IA, Hand CK, Dubé MP, MacGregor DL, Seni MH, Devon RS, Hayden MR, Andermann F, Andermann E, Rouleau GA. An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred. Ann. Neurol. 53(1):144-5. (2003) PMID 12509863
Laurent C, Niehaus D, Bauché S, Levinson DF, Soubigou S, Pimstone S, Hayden M, Mbanga I, Emsley R, Deleuze JF, Mallet J. CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 116B(1):45-50. (2003) PMID 12497613
Beever CL, Stephenson MD, Peñaherrera MS, Jiang RH, Kalousek DK, Hayden M, Field L, Brown CJ, Robinson WP. Skewed X-chromosome inactivation is associated with trisomy in women ascertained on the basis of recurrent spontaneous abortion or chromosomally abnormal pregnancies. Am. J. Hum. Genet. 72(2):399-407. (2003) PMID 12497247
Nucifora FC, Ellerby LM, Wellington CL, Wood JD, Herring WJ, Sawa A, Hayden MR, Dawson VL, Dawson TM, Ross CA. Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity. J. Biol. Chem. 278(15):13047-55. (2003) PMID 12464607
Wellington CL, Yang YZ, Zhou S, Clee SM, Tan B, Hirano K, Zwarts K, Kwok A, Gelfer A, Marcil M, Newman S, Roomp K, Singaraja R, Collins J, Zhang LH, Groen AK, Hovingh K, Brownlie A, Tafuri S, Genest J, Kastelein JJ, Hayden MR. Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. J. Lipid Res. 43(11):1939-49. (2002) PMID 12401893
Attie AD, Krauss RM, Gray-Keller MP, Brownlie A, Miyazaki M, Kastelein JJ, Lusis AJ, Stalenhoef AF, Stoehr JP, Hayden MR, Ntambi JM. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J. Lipid Res. 43(11):1899-907. (2002) PMID 12401889
Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum. Mol. Genet. 11(23):2815-28. (2002) PMID 12393793
Attie AD, Hamon Y, Brooks-Wilson AR, Gray-Keller MP, MacDonald ML, Rigot V, Tebon A, Zhang LH, Mulligan JD, Singaraja RR, Bitgood JJ, Cook ME, Kastelein JJ, Chimini G, Hayden MR. Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken. J. Lipid Res. 43(10):1610-7. (2002) PMID 12364545
Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease. J. Neurosci. 22(18):7862-72. (2002) PMID 12223539
See RH, Caday-Malcolm RA, Singaraja RR, Zhou S, Silverston A, Huber MT, Moran J, James ER, Janoo R, Savill JM, Rigot V, Zhang LH, Wang M, Chimini G, Wellington CL, Tafuri SR, Hayden MR. Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux. J. Biol. Chem. 277(44):41835-42. (2002) PMID 12196520
Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dubé MP, Zhang LH, Singaraja RR, Guernsey DL, Zheng B, Siebert LF, Hoskin-Mott A, Trese MT, Pimstone SN, Shastry BS, Moon RT, Hayden MR, Goldberg YP, Samuels ME. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat. Genet. 32(2):326-30. (2002) PMID 12172548
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Defesche JC, Van Diermen DE, Hayden MR, Kastelein JP. Origin and migration of an Afrikaner founder mutation FHAfrikaner-2 (V408M) causing familial hypercholesterolemia. 10(1):1-10. (1996) PMID 8913716
Nasir J, Goldberg YP, Hayden MR. Huntington disease: new insights into the relationship between CAG expansion and disease. Hum. Mol. Genet. 5 Spec No:1431-5. (1996) PMID 8875248
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Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK, Bromm M, Kazemi-Esfarjani P, Thornberry NA, Vaillancourt JP, Hayden MR. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat. Genet. 13(4):442-9. (1996) PMID 8696339
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Shen GX, Zhang JY, Blanchard R, Zhang HF, Hayden M, McPherson R, Angel A. Analysis of cholesteryl ester transfer activity in adipose tissue. Int. J. Obes. Relat. Metab. Disord. 20 Suppl 3:S114-20. (1996) PMID 8680471
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Nasir J, Floresco SB, O'Kusky JR, Diewert VM, Richman JM, Zeisler J, Borowski A, Marth JD, Phillips AG, Hayden MR. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 81(5):811-23. (1995) PMID 7774020
Estabrooks LL, Breg WR, Hayden MR, Ledbetter DH, Myers RM, Wyandt HE, Yang-Feng TL, Hirschhorn K. Summary of the 1993 ASHG ancillary meeting "recent research on chromosome 4p syndromes and genes". Am. J. Med. Genet. 55(4):453-8. (1995) PMID 7762585
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Zhang H, Reymer PW, Liu MS, Forsythe IJ, Groenemeyer BE, Frohlich J, Brunzell JD, Kastelein JJ, Hayden MR, Ma Y. Patients with apoE3 deficiency (E2/2, E3/2, and E4/2) who manifest with hyperlipidemia have increased frequency of an Asn 291-->Ser mutation in the human LPL gene. Arterioscler. Thromb. Vasc. Biol. 15(10):1695-703. (1995) PMID 7583546
Lewis ME, Forsythe IJ, Marth JD, Brunzell JD, Hayden MR, Humphries RK. Retroviral-mediated gene transfer and expression of human lipoprotein lipase in somatic cells. Hum. Gene Ther. 6(7):853-63. (1995) PMID 7578404
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Riess O, Thies U, Siedlaczck I, Potisek S, Graham R, Theilmann J, Grimm T, Epplen JT, Hayden MR. Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16. Genomics 19(2):298-302. (1994) PMID 8188260
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Andrew SE, Goldberg YP, Theilmann J, Zeisler J, Hayden MR. A CCG repeat polymorphism adjacent to the CAG repeat in the Huntington disease gene: implications for diagnostic accuracy and predictive testing. Hum. Mol. Genet. 3(1):65-7. (1994) PMID 8162053
Kremer B, Goldberg P, Andrew SE, Theilmann J, Telenius H, Zeisler J, Squitieri F, Lin B, Bassett A, Almqvist E. A worldwide study of the Huntington's disease mutation. The sensitivity and specificity of measuring CAG repeats. N. Engl. J. Med. 330(20):1401-6. (1994) PMID 8159192
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Bijvoet SM, Bruin T, Tuzgöl S, Bakker HD, Hayden MR, Kastelein JJ. Homozygosity for a mutation in the lipoprotein lipase gene (Gly139-->Ser) causes chylomicronaemia in a boy of Spanish descent. Hum. Genet. 93(3):339-43. (1994) PMID 8125488
Davignon J, Roederer G, Montigny M, Hayden MR, Tan MH, Connelly PW, Hegele R, McPherson R, Lupien PJ, Gagné C. Comparative efficacy and safety of pravastatin, nicotinic acid and the two combined in patients with hypercholesterolemia. Am. J. Cardiol. 73(5):339-45. (1994) PMID 8109547
Ma Y, Ooi TC, Liu MS, Zhang H, McPherson R, Edwards AL, Forsythe IJ, Frohlich J, Brunzell JD, Hayden MR. High frequency of mutations in the human lipoprotein lipase gene in pregnancy-induced chylomicronemia: possible association with apolipoprotein E2 isoform. J. Lipid Res. 35(6):1066-75. (1994) PMID 8077845
Karlinsky H, Sadovnick AD, Burgess MM, Langlois S, Hayden MR, Berg JM. Issues in molecular genetic testing of individuals with suspected early-onset familial Alzheimer's disease. 8(2):116-25. (1994) PMID 8060604
Telenius H, Kremer B, Goldberg YP, Theilmann J, Andrew SE, Zeisler J, Adam S, Greenberg C, Ives EJ, Clarke LA. Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm. Nat. Genet. 6(4):409-14. (1994) PMID 8054984
Gagné E, Genest J, Zhang H, Clarke LA, Hayden MR. Analysis of DNA changes in the LPL gene in patients with familial combined hyperlipidemia. Arterioscler. Thromb. 14(8):1250-7. (1994) PMID 8049185
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Hayden MR, Liu MS, Ma Y. Gene environment interaction and plasma triglyceride levels: the crucial role of lipoprotein lipase. Clin. Genet. 46(1 Spec No):15-8. (1994) PMID 7988072
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Nasir J, Lin B, Bucan M, Koizumi T, Nadeau JH, Hayden MR. The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3. Genomics 22(1):198-201. (1994) PMID 7959767
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Bruin T, Tuzgöl S, Mulder WJ, van den Ende AE, Jansen H, Hayden MR, Kastelein JJ. A compound heterozygote for lipoprotein lipase deficiency, Val69-->Leu and Gly188-->Glu: correlation between in vitro LPL activity and clinical expression. J. Lipid Res. 35(3):438-45. (1994) PMID 7912254
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Ma Y, Henderson HE, Liu MS, Zhang H, Forsythe IJ, Clarke-Lewis I, Hayden MR, Brunzell JD. Mutagenesis in four candidate heparin binding regions (residues 279-282, 291-304, 390-393, and 439-448) and identification of residues affecting heparin binding of human lipoprotein lipase. J. Lipid Res. 35(11):2049-59. (1994) PMID 7868983
Tuzgöl S, Bijvoet SM, Bruin T, Kastelein JJ, Hayden MR. Apolipoprotein CII-Padova (Tyr37-->stop) as a cause of chylomicronaemia in an Italian kindred from Siculiana. J. Med. Genet. 31(8):622-6. (1994) PMID 7815420
Clarke LA, Nasir J, Zhang H, McDonald H, Applegarth DA, Hayden MR, Toone J. Murine alpha-L-iduronidase: cDNA isolation and expression. Genomics 24(2):311-6. (1994) PMID 7698753
Ma Y, Liu MS, Ginzinger D, Frohlich J, Brunzell JD, Hayden MR. Gene-environment interaction in the conversion of a mild-to-severe phenotype in a patient homozygous for a Ser172-->Cys mutation in the lipoprotein lipase gene. J. Clin. Invest. 91(5):1953-8. (1993) PMID 8486765
Dionne C, Gagné C, Julien P, Murthy MR, Roederer G, Davignon J, Lambert M, Chitayat D, Ma R, Henderson H. Genealogy and regional distribution of lipoprotein lipase deficiency in French-Canadians of Quebec. Hum. Biol. 65(1):29-39. (1993) PMID 8436388
Funke H, von Eckardstein A, Pritchard PH, Hornby AE, Wiebusch H, Motti C, Hayden MR, Dachet C, Jacotot B, Gerdes U. Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency. Six newly identified defective alleles further contribute to the structural heterogeneity in this disease. J. Clin. Invest. 91(2):677-83. (1993) PMID 8432868
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Collins C, Duff C, Duncan AM, Planells-Cases R, Sun W, Norremolle A, Michaelis E, Montal M, Worton R, Hayden MR. Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. Genomics 17(1):237-9. (1993) PMID 8406459
Andrew SE, Goldberg YP, Kremer B, Telenius H, Theilmann J, Adam S, Starr E, Squitieri F, Lin B, Kalchman MA. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat. Genet. 4(4):398-403. (1993) PMID 8401589
Weber B, Riess O, Daneshvar H, Graham R, Hayden MR. (CA)n-dinucleotide repeat at the PDEB locus in 4p16.3. Hum. Mol. Genet. 2(6):827. (1993) PMID 8394765
Hutchinson GB, Andrew SE, McDonald H, Goldberg YP, Graham R, Rommens JM, Hayden MR. An Alu element retroposition in two families with Huntington disease defines a new active Alu subfamily. Nucleic Acids Res. 21(15):3379-83. (1993) PMID 8393987
Goldberg YP, Rommens JM, Andrew SE, Hutchinson GB, Lin B, Theilmann J, Graham R, Glaves ML, Starr E, McDonald H. Identification of an Alu retrotransposition event in close proximity to a strong candidate gene for Huntington's disease. Nature 362(6418):370-3. (1993) PMID 8384324
Hayden MR. On planting alfalfa and growing orchids: the cloning of the gene causing Huntington disease. Clin. Genet. 43(5):217-22. (1993) PMID 8375101
Andrew S, Theilmann J, Almqvist E, Norremolle A, Lucotte G, Anvret M, Sorensen SA, Turpin JC, Hayden MR. DNA analysis of distinct populations suggests multiple origins for the mutation causing Huntington disease. Clin. Genet. 43(6):286-94. (1993) PMID 8370147
Ma Y, Liu MS, Zhang H, Forsythe IJ, Brunzell JD, Hayden MR. A 4 basepair deletion in exon 4 of the human lipoprotein lipase gene results in type I hyperlipoproteinemia. Hum. Mol. Genet. 2(7):1049-50. (1993) PMID 8364543
Hayden MR, Kastelein JJ, Funke H, Brunzell JD, Ma Y. Phenotypic variation of mutations in the human lipoprotein-lipase gene. Biochem. Soc. Trans. 21(2):506-9. (1993) PMID 8359520
Goldberg YP, Andrew SE, Clarke LA, Hayden MR. A PCR method for accurate assessment of trinucleotide repeat expansion in Huntington disease. Hum. Mol. Genet. 2(6):635-6. (1993) PMID 8353482
Frohlich J, Brun LD, Blank D, Campeau L, Crockford P, Curnew G, Dafoe W, Davignon J, Dufour R, Emery G. Comparison of the short term efficacy and tolerability of lovastatin and simvastatin in the management of primary hypercholesterolemia. 9(5):405-12. (1993) PMID 8348392
Durbach N, Hayden MR. George Huntington: the man behind the eponym. J. Med. Genet. 30(5):406-9. (1993) PMID 8320704
Bruin T, Tuzgöl S, van Diermen DE, Hoogerbrugge-van der Linden N, Brunzell JD, Hayden MR, Kastelein JJ. Recurrent pancreatitis and chylomicronemia in an extended Dutch kindred is caused by a Gly154-->Ser substitution in lipoprotein lipase. J. Lipid Res. 34(12):2109-19. (1993) PMID 8301230
Telenius H, Kremer HP, Theilmann J, Andrew SE, Almqvist E, Anvret M, Greenberg C, Greenberg J, Lucotte G, Squitieri F. Molecular analysis of juvenile Huntington disease: the major influence on (CAG)n repeat length is the sex of the affected parent. Hum. Mol. Genet. 2(10):1535-40. (1993) PMID 8268906
Goldberg YP, Kremer B, Andrew SE, Theilmann J, Graham RK, Squitieri F, Telenius H, Adam S, Sajoo A, Starr E. Molecular analysis of new mutations for Huntington's disease: intermediate alleles and sex of origin effects. Nat. Genet. 5(2):174-9. (1993) PMID 8252043
Babul R, Adam S, Kremer B, Dufrasne S, Wiggins S, Huggins M, Theilmann J, Bloch M, Hayden MR. Attitudes toward direct predictive testing for the Huntington disease gene. Relevance for other adult-onset disorders. The Canadian Collaborative Group on Predictive Testing for Huntington Disease. JAMA 270(19):2321-5. (1993) PMID 8230594
Henderson HE, Ma Y, Liu MS, Clark-Lewis I, Maeder DL, Kastelein JJ, Brunzell JD, Hayden MR. Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region. J. Lipid Res. 34(9):1593-602. (1993) PMID 8228642
Defesche JC, Pricker KL, Hayden MR, van der Ende BE, Kastelein JJ. Familial defective apolipoprotein B-100 is clinically indistinguishable from familial hypercholesterolemia. Arch. Intern. Med. 153(20):2349-56. (1993) PMID 8215738
Hayden MR, Josephson R. Development of a program for identification of patients with familial hypercholesterolemia in British Columbia: a model for prevention of coronary disease. Am. J. Cardiol. 72(10):25D-29D. (1993) PMID 8213493
Bloch M, Adam S, Fuller A, Kremer B, Welch JP, Wiggins S, Whyte P, Huggins M, Theilmann J, Hayden MR. Diagnosis of Huntington disease: a model for the stages of psychological response based on experience of a predictive testing program. Am. J. Med. Genet. 47(3):368-74. (1993) PMID 8135283
Kremer B, Squitieri F, Telenius H, Andrew SE, Theilmann J, Spence N, Goldberg YP, Hayden MR. Molecular analysis of late onset Huntington's disease. J. Med. Genet. 30(12):991-5. (1993) PMID 8133510
Goldberg YP, Andrew SE, Theilmann J, Kremer B, Squitieri F, Telenius H, Brown JD, Hayden MR. Familial predisposition to recurrent mutations causing Huntington's disease: genetic risk to sibs of sporadic cases. J. Med. Genet. 30(12):987-90. (1993) PMID 8133509
McGeer EG, Kremer B, Hayden MR. Monoamines and their metabolites in Huntington's disease brain: evidence for decreased catechol-O-methyltransferase activity. Biol. Psychiatry 33(7):551-3. (1993) PMID 8099814
Wood S, Schertzer M, Hayden M, Ma Y. Support for founder effect for two lipoprotein lipase (LPL) gene mutations in French Canadians by analysis of GT microsatellites flanking the LPL gene. Hum. Genet. 91(4):312-6. (1993) PMID 8099055
Zambon A, Torres A, Bijvoet S, Gagne C, Moorjani S, Lupien PJ, Hayden MR, Brunzell JD. Prevention of raised low-density lipoprotein cholesterol in a patient with familial hypercholesterolaemia and lipoprotein lipase deficiency. Lancet 341(8853):1119-21. (1993) PMID 8097805
Lin B, Rommens JM, Graham RK, Kalchman M, MacDonald H, Nasir J, Delaney A, Goldberg YP, Hayden MR. Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression. Hum. Mol. Genet. 2(10):1541-5. (1993) PMID 7903579
Defesche JC, van Diermen DE, Lansberg PJ, Lamping RJ, Reymer PW, Hayden MR, Kastelein JJ. South African founder mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia in the Dutch population. Hum. Genet. 92(6):567-70. (1993) PMID 7903269
Rommens JM, Lin B, Hutchinson GB, Andrew SE, Goldberg YP, Glaves ML, Graham R, Lai V, McArthur J, Nasir J. A transcription map of the region containing the Huntington disease gene. Hum. Mol. Genet. 2(7):901-7. (1993) PMID 7689900
Tooyama I, Kremer HP, Hayden MR, Kimura H, McGeer EG, McGeer PL. Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease. Brain Res. 610(1):1-7. (1993) PMID 7686078
Ma YH, Bruin T, Tuzgol S, Wilson BI, Roederer G, Liu MS, Davignon J, Kastelein JJ, Brunzell JD, Hayden MR. Two naturally occurring mutations at the first and second bases of codon aspartic acid 156 in the proposed catalytic triad of human lipoprotein lipase. In vivo evidence that aspartic acid 156 is essential for catalysis. J. Biol. Chem. 267(3):1918-23. (1992) PMID 1730727
Bergeron J, Normand T, Bharucha A, Ven Murthy MR, Julien P, Gagné C, Dionne C, De Braekeleer M, Brun D, Hayden MR. Prevalence, geographical distribution and genealogical investigations of mutation 188 of lipoprotein lipase gene in the French Canadian population of Québec. Clin. Genet. 41(4):206-10. (1992) PMID 1576758
Bloch M, Adam S, Wiggins S, Huggins M, Hayden MR. Predictive testing for Huntington disease in Canada: the experience of those receiving an increased risk. Am. J. Med. Genet. 42(4):499-507. (1992) PMID 1535177
Huggins M, Hayden MR. Predictive testing for Huntington disease. 18(1):47-8. (1992) PMID 1533425
Martin WR, Clark C, Ammann W, Stoessl AJ, Shtybel W, Hayden MR. Cortical glucose metabolism in Huntington's disease. Neurology 42(1):223-9. (1992) PMID 1531155
Dionne C, Gagné C, Julien P, Murthy MR, Lambert M, Roederer G, Davignon J, Hayden MR, Lupien PJ, de Braekeleer M. Genetic epidemiology of lipoprotein lipase deficiency in Saguenay-Lac-St-Jean (Québec, Canada). Ann. Genet. 35(2):89-92. (1992) PMID 1524414
Bruin T, Kastelein JJ, Van Diermen DE, Ma Y, Henderson HE, Stuyt PM, Stalenhoef AF, Sturk A, Brunzell JD, Hayden MR. A missense mutation Pro157 Arg in lipoprotein lipase (LPLNijmegen) resulting in loss of catalytic activity. Eur. J. Biochem. 208(2):267-72. (1992) PMID 1521525
Hayden MR, Ma Y. Molecular genetics of human lipoprotein lipase deficiency. Mol. Cell. Biochem. 113(2):171-6. (1992) PMID 1518507
Normand T, Bergeron J, Fernandez-Margallo T, Bharucha A, Ven Murthy MR, Julien P, Gagné C, Dionne C, De Braekeleer M, Ma R. Geographic distribution and genealogy of mutation 207 of the lipoprotein lipase gene in the French Canadian population of Québec. Hum. Genet. 89(6):671-5. (1992) PMID 1511985
Defesche JC, van de Ree MA, Kastelein JJ, van Diermen DE, Janssens NW, van Doormaal JJ, Hayden MR. Detection of the Pro664-Leu mutation in the low-density lipoprotein receptor and its relation to lipoprotein(a) levels in patients with familial hypercholesterolemia of Dutch ancestry from The Netherlands and Canada. Clin. Genet. 42(6):273-80. (1992) PMID 1493640
Wiggins S, Whyte P, Huggins M, Adam S, Theilmann J, Bloch M, Sheps SB, Schechter MT, Hayden MR. The psychological consequences of predictive testing for Huntington's disease. Canadian Collaborative Study of Predictive Testing. N. Engl. J. Med. 327(20):1401-5. (1992) PMID 1406858
Liu MS, Ma Y, Hayden MR, Brunzell JD. Mapping of the epitope on lipoprotein lipase recognized by a monoclonal antibody (5D2) which inhibits lipase activity. Biochim. Biophys. Acta 1128(1):113-5. (1992) PMID 1382603
Henderson HE, Hassan F, Berger GM, Hayden MR. The lipoprotein lipase Gly188----Glu mutation in South Africans of Indian descent: evidence suggesting common origins and an increased frequency. J. Med. Genet. 29(2):119-22. (1992) PMID 1351946
Andrew S, Theilmann J, Hedrick A, Mah D, Weber B, Hayden MR. Nonrandom association between Huntington disease and two loci separated by about 3 Mb on 4p16.3. Genomics 13(2):301-11. (1992) PMID 1351866
Weber B, Hedrick A, Andrew S, Riess O, Collins C, Kowbel D, Hayden MR. Isolation and characterization of new highly polymorphic DNA markers from the Huntington disease region. Am. J. Hum. Genet. 50(2):382-93. (1992) PMID 1346482
Weber B, Riess O, Wolff G, Andrew S, Collins C, Graham R, Theilmann J, Hayden MR. Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease. Nat. Genet. 2(3):216-22. (1992) PMID 1345172
Kremer B, Weber B, Hayden MR. New insights into the clinical features, pathogenesis and molecular genetics of Huntington disease. Brain Pathol. 2(4):321-35. (1992) PMID 1341966
Riess O, Noerremoelle A, Collins C, Mah D, Weber B, Hayden MR. Exclusion of DNA changes in the beta-subunit of the c-GMP phosphodiesterase gene as the cause for Huntington's disease. Nat. Genet. 1(2):104-8. (1992) PMID 1338767
Riess O, Weber B, Noeremolle A, Shaikh RA, Hayden MR, Musarella MA. Linkage studies and mutation analysis of the PDEB gene in 23 families with Leber congenital amaurosis. Hum. Mutat. 1(6):478-85. (1992) PMID 1338765
Riess O, Weber B, Hayden MR. (CA)n-dinucleotide repeat polymorphism at the locus for the alpha2C adrenergic receptor (ADRA2C) on 4p16. Hum. Mol. Genet. 1(6):452. (1992) PMID 1338762
Liang XR. [Postoperative care of multiple familial colonic polyposis] 27(11):498-9. (1992) PMID 1338715
Riess O, Noerremoelle A, Weber B, Musarella MA, Hayden MR. The search for mutations in the gene for the beta subunit of the cGMP phosphodiesterase (PDEB) in patients with autosomal recessive retinitis pigmentosa. Am. J. Hum. Genet. 51(4):755-62. (1992) PMID 1329504
Collins C, Hutchinson G, Kowbel D, Riess O, Weber B, Hayden MR. The human beta-subunit of rod photoreceptor cGMP phosphodiesterase: complete retinal cDNA sequence and evidence for expression in brain. Genomics 13(3):698-704. (1992) PMID 1322354
Hutchinson GB, Hayden MR. The prediction of exons through an analysis of spliceable open reading frames. Nucleic Acids Res. 20(13):3453-62. (1992) PMID 1321415
Bijvoet SM, Hayden MR. Mismatch PCR: a rapid method to screen for the Pro207-->Leu mutation in the lipoprotein lipase (LPL) gene. Hum. Mol. Genet. 1(7):541. (1992) PMID 1307255
Collins C, Schappert K, Hayden MR. The genomic organization of a novel regulatory myosin light chain gene (MYL5) that maps to chromosome 4p16.3 and shows different patterns of expression between primates. Hum. Mol. Genet. 1(9):727-33. (1992) PMID 1284596
Goldberg YP, Lin BY, Andrew SE, Nasir J, Graham R, Glaves ML, Hutchinson G, Theilmann J, Ginzinger DG, Schappert K. Cloning and mapping of the alpha-adducin gene close to D4S95 and assessment of its relationship to Huntington disease. Hum. Mol. Genet. 1(9):669-75. (1992) PMID 1284592
Ma Y, Henderson HE, Murthy V, Roederer G, Monsalve MV, Clarke LA, Normand T, Julien P, Gagné C, Lambert M. A mutation in the human lipoprotein lipase gene as the most common cause of familial chylomicronemia in French Canadians. N. Engl. J. Med. 324(25):1761-6. (1991) PMID 2038366
Hill JS, Hayden MR, Frohlich J, Pritchard PH. Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia. Arterioscler. Thromb. 11(2):290-7. (1991) PMID 1998646
Weber B, Collins C, Kowbel D, Riess O, Hayden MR. Identification of multiple CpG islands and associated conserved sequences in a candidate region for the Huntington disease gene. Genomics 11(4):1113-24. (1991) PMID 1838348
Hayden MR. Predictive testing for Huntington disease: are we ready for widespread community implementation? Am. J. Med. Genet. 40(4):515-7. (1991) PMID 1836106
Greenberg LJ, Martell RW, Theilman J, Hayden MR, Joubert J. Genetic linkage between Huntington disease and the D4S10 locus in South African families: further evidence against non-allelic heterogeneity. Hum. Genet. 87(6):701-8. (1991) PMID 1834541
Clark CM, Ammann W, Martin WR, Ty P, Hayden MR. The FDG/PET methodology for early detection of disease onset: a statistical model. J. Cereb. Blood Flow Metab. 11(2):A96-102. (1991) PMID 1825496
Weber B, Allen L, Magenis RE, Goodfellow PJ, Smith L, Hayden MR. Intrachromosomal location of the telomeric repeat (TTAGGG)n. Mamm. Genome 1(4):211-6. (1991) PMID 1794050
Weber B, Allen L, Magenis RE, Hayden MR. A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini. Cytogenet. Cell Genet. 57(4):179-83. (1991) PMID 1743071
Weber B, Riess O, Hutchinson G, Collins C, Lin BY, Kowbel D, Andrew S, Schappert K, Hayden MR. Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3. Nucleic Acids Res. 19(22):6263-8. (1991) PMID 1720239
Henderson HE, Ma Y, Hassan MF, Monsalve MV, Marais AD, Winkler F, Gubernator K, Peterson J, Brunzell JD, Hayden MR. Amino acid substitution (Ile194----Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands. Support for a multicentric origin. J. Clin. Invest. 87(6):2005-11. (1991) PMID 1674945
Weber B, Riess O, Kreklywich CN, Wood S, Hayden MR. A polymorphic DNA marker at the D8S131 locus. Nucleic Acids Res. 19(7):1725. (1991) PMID 1674144
Weber B, Riess O, Hayden MR. A polymorphic DNA marker at the D10S106 locus. Nucleic Acids Res. 19(7):1725. (1991) PMID 1674143
Adam S, Theilmann J, Buetow K, Hedrick A, Collins C, Weber B, Huggins M, Hayden M. Linkage disequilibrium and modification of risk for Huntington disease. Am. J. Hum. Genet. 48(3):595-603. (1991) PMID 1671809
Eisen A, Bohlega S, Bloch M, Hayden M. Silent periods, long-latency reflexes and cortical MEPs in Huntington's disease and at-risk relatives. Electroencephalogr Clin Neurophysiol 74(6):444-9. (1990) PMID 2480224
Clark C, Klonoff H, Hayden M. Regional cerebral glucose metabolism in Turner syndrome. 17(2):140-4. (1990) PMID 2357649
Weber B, Collins C, Robbins C, Magenis RE, Delaney AD, Gray JW, Hayden MR. Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)n. Nucleic Acids Res. 18(11):3353-61. (1990) PMID 2356126
Devlin RH, Deeb S, Brunzell J, Hayden MR. Partial gene duplication involving exon-Alu interchange results in lipoprotein lipase deficiency. Am. J. Hum. Genet. 46(1):112-9. (1990) PMID 2294743
Peritz LN, Brunzell JD, Harvey-Clarke C, Pritchard PH, Jones BR, Hayden MR. Characterization of a lipoprotein lipase class III type defect in hypertriglyceridemic cats. 13(5):259-63. (1990) PMID 2276220
Bloch M, Hayden MR. DNA testing for Huntington disease results in a modification of risk and not diagnosis of disease. Eur. J. Pediatr. 149(7):513. (1990) PMID 2140774
Bloch M, Hayden MR. Opinion: predictive testing for Huntington disease in childhood: challenges and implications. Am. J. Hum. Genet. 46(1):1-4. (1990) PMID 2136787
Henderson HE, Devlin R, Peterson J, Brunzell JD, Hayden MR. Frameshift mutation in exon 3 of the lipoprotein lipase gene causes a premature stop codon and lipoprotein lipase deficiency. Mol. Biol. Med. 7(6):511-7. (1990) PMID 2077351
Monsalve MV, Henderson H, Roederer G, Julien P, Deeb S, Kastelein JJ, Peritz L, Devlin R, Bruin T, Murthy MR. A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries. J. Clin. Invest. 86(3):728-34. (1990) PMID 1975597
Huggins M, Bloch M, Kanani S, Quarrell OW, Theilman J, Hedrick A, Dickens B, Lynch A, Hayden M. Ethical and legal dilemmas arising during predictive testing for adult-onset disease: the experience of Huntington disease. Am. J. Hum. Genet. 47(1):4-12. (1990) PMID 1971997
Kastelein JJ, Haines JL, Hayden MR. The gene causing familial hypoalphalipoproteinemia is not caused by a defect in the apo AI-CIII-AIV gene cluster in a Spanish family. Hum. Genet. 84(5):396-400. (1990) PMID 1969839
Lowry RB, Wood BJ, Cox TA, Hayden MR. Epiphyseal dysplasia, microcephaly, nystagmus, and retinitis pigmentosa. Am. J. Med. Genet. 33(3):341-5. (1989) PMID 2801768
Gilchrist DM, Hayden MR. Marfan's syndrome. 141(7):656-7. (1989) PMID 2790594
Hayden MR. The genetic aspects of atherosclerosis and hyperlipidemia. 141(2):135. (1989) PMID 2743228
Chitayat D, Davis EB, McGillivray BC, Hayden MR, Hall JG. Perinatal and first year follow-up of patients with Prader-Willi syndrome: normal size of hands and feet. Clin. Genet. 35(3):161-6. (1989) PMID 2706799
Quarrell OW, Bloch M, Hayden MR. Insurance and the presymptomatic diagnosis of delayed-onset disease. JAMA 262(17):2384-5. (1989) PMID 2619811
Conneally PM, Haines JL, Tanzi RE, Wexler NS, Penchaszadeh GK, Harper PS, Folstein SE, Cassiman JJ, Myers RH, Young AB. Huntington disease: no evidence for locus heterogeneity. Genomics 5(2):304-8. (1989) PMID 2571579
Gessler M, Thomas GH, Couillin P, Junien C, McGillivray BC, Hayden M, Jaschek G, Bruns GA. A deletion map of the WAGR region on chromosome 11. Am. J. Hum. Genet. 44(4):486-95. (1989) PMID 2539014
Langlois S, Deeb S, Brunzell JD, Kastelein JJ, Hayden MR. A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency. Proc. Natl. Acad. Sci. U.S.A. 86(3):948-52. (1989) PMID 2536938
Theilmann J, Kanani S, Shiang R, Robbins C, Quarrell O, Huggins M, Hedrick A, Weber B, Collins C, Wasmuth JJ. Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene. J. Med. Genet. 26(11):676-81. (1989) PMID 2531224
Theilmann JL, Robbins CA, Hayden MR. Methylation at the D4S95 locus and predictive testing. Am. J. Hum. Genet. 45(3):477-9. (1989) PMID 2528290
Fahy M, Robbins C, Bloch M, Turnell RW, Hayden MR. Different options for prenatal testing for Huntington's disease using DNA probes. J. Med. Genet. 26(6):353-7. (1989) PMID 2525622
Bloch M, Fahy M, Fox S, Hayden MR. Predictive testing for Huntington disease: II. Demographic characteristics, life-style patterns, attitudes, and psychosocial assessments of the first fifty-one test candidates. Am. J. Med. Genet. 32(2):217-24. (1989) PMID 2522735
Fox S, Bloch M, Fahy M, Hayden MR. Predictive testing for Huntington disease: I. Description of a pilot project in British Columbia. Am. J. Med. Genet. 32(2):211-6. (1989) PMID 2522734
Robbins C, Theilmann J, Youngman S, Haines J, Altherr MJ, Harper PS, Payne C, Junker A, Wasmuth J, Hayden MR. Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90. Am. J. Hum. Genet. 44(3):422-5. (1989) PMID 2521771
Chitayat D, Lao A, Wilson RD, Fagerstrom C, Hayden M. Prenatal diagnosis of asplenia/polysplenia syndrome. Am. J. Obstet. Gynecol. 158(5):1085-7. (1988) PMID 3369489
Bamforth S, Hayden MR. Pulmonary emphysema in neonate with the Marfan syndrome. 18(1):88. (1988) PMID 3340437
Makrides SC, Ruiz-Opazo N, Hayden M, Nussbaum AL, Breslow JL, Zannis VI. Sequence and expression of Tangier apoA-I gene. Eur. J. Biochem. 173(2):465-71. (1988) PMID 3129297
Rabkin SW, Hayden M, Frohlich J. Comparison of gemfibrozil and clofibrate on serum lipids in familial combined hyperlipidemia. A randomized placebo-controlled, double-blind, crossover clinical trial. Atherosclerosis 73(2-3):233-40. (1988) PMID 3056431
Hayden MR, Robbins C, Allard D, Haines J, Fox S, Wasmuth J, Fahy M, Bloch M. Improved predictive testing for Huntington disease by using three linked DNA markers. Am. J. Hum. Genet. 43(5):689-94. (1988) PMID 2973229
Lam RW, Bloch M, Jones BD, Marcus AM, Fox S, Amman W, Hayden MR. Psychiatric morbidity associated with early clinical diagnosis of Huntington disease in a predictive testing program. 49(11):444-7. (1988) PMID 2972696
Hayden MR, Bloch M, Fahy M. Predictive testing for Huntington's disease using linked DNA markers. N. Engl. J. Med. 319(9):583-4. (1988) PMID 2970011
Jason GW, Pajurkova EM, Suchowersky O, Hewitt J, Hilbert C, Reed J, Hayden MR. Presymptomatic neuropsychological impairment in Huntington's disease. Arch. Neurol. 45(7):769-73. (1988) PMID 2968784
Wasmuth JJ, Hewitt J, Smith B, Allard D, Haines JL, Skarecky D, Partlow E, Hayden MR. A highly polymorphic locus very tightly linked to the Huntington's disease gene. Nature 332(6166):734-6. (1988) PMID 2895895
Hayden MR, Hewitt J, Wasmuth JJ, Kastelein JJ, Langlois S, Conneally M, Haines J, Smith B, Hilbert C, Allard D. A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene. Am. J. Hum. Genet. 42(1):125-31. (1988) PMID 2892395
Langlois S, Kastelein JJ, Hayden MR. Characterization of six partial deletions in the low-density-lipoprotein (LDL) receptor gene causing familial hypercholesterolemia (FH). Am. J. Hum. Genet. 43(1):60-8. (1988) PMID 2837085
Frohlich J, Fong B, Julien P, Despres JP, Angel A, Hayden M, McLeod R, Chow C, Davison RH, Pritchard H. Interaction of high density lipoprotein with adipocytes in a new patient with Tangier disease. 10(5):377-82. (1987) PMID 3677505
Frohlich J, Hoag G, McLeod R, Hayden M, Godin DV, Wadsworth LD, Critchley JD, Pritchard PH. Hypoalphalipoproteinemia resembling fish eye disease. 221(3):291-8. (1987) PMID 3591467
Hayden MR, Kastelein JJ, Langlois S. Insufficient evidence to invoke defects in or around the A-I gene as the cause for familial hypoalphalipoproteinemia. Atherosclerosis 67(2-3):271-2. (1987) PMID 3118895
Swart AL, Hesseling PB, Hayden MR, Louw M, Herbert JS. Gaucher's disease in the Cape coloured population of the RSA, including a family with 5 affected siblings. S. Afr. Med. J. 71(2):97-9. (1987) PMID 3101207
Martin WR, Hayden MR. Cerebral glucose and dopa metabolism in movement disorders. 14(3 Suppl):448-51. (1987) PMID 2960430
Bloch M, Hayden MR. Preclinical testing in Huntington disease. Am. J. Med. Genet. 27(3):733-4. (1987) PMID 2957915
Hayden MR, Hewitt J, Stoessl AJ, Clark C, Ammann W, Martin WR. The combined use of positron emission tomography and DNA polymorphisms for preclinical detection of Huntington's disease. Neurology 37(9):1441-7. (1987) PMID 2957611
Clark C, Hayden M, Hollenberg S, Li D, Stoessl AJ. Controlling for cerebral atrophy in positron emission tomography data. J. Cereb. Blood Flow Metab. 7(4):510-2. (1987) PMID 2956273
Hayden MR, Goldblatt J, Wallis G, Winship IM, Beighton P. Molecular genetics and Huntington's disease. The South African situation. S. Afr. Med. J. 71(11):683-6. (1987) PMID 2954228
Talmud PJ, Barni N, Kessling AM, Carlsson P, Darnfors C, Bjursell G, Galton D, Wynn V, Kirk H, Hayden MR. Apolipoprotein B gene variants are involved in the determination of serum cholesterol levels: a study in normo- and hyperlipidaemic individuals. Atherosclerosis 67(1):81-9. (1987) PMID 2890359
MacDonald ME, Anderson MA, Gilliam TC, Tranejaerg L, Carpenter NJ, Magenis E, Hayden MR, Healey ST, Bonner TI, Gusella JF. A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene. Genomics 1(1):29-34. (1987) PMID 2889660
Hayden MR, Hewitt J, Maresca A, Langlois S. A polymorphic DNA probe located to human chromosome 4p16 (D4S62). Nucleic Acids Res. 15(9):3938. (1987) PMID 2884639
Hayden MR, Hewitt J, Kastelein JJ, Langlois S, Wilson RD, Fox S, Hilbert C, Bloch M. First-trimester prenatal diagnosis for Huntington's disease with DNA probes. Lancet 1(8545):1284-5. (1987) PMID 2884412
Hayden MR, Kirk H, Clark C, Frohlich J, Rabkin S, McLeod R, Hewitt J. DNA polymorphisms in and around the Apo-A1-CIII genes and genetic hyperlipidemias. Am. J. Hum. Genet. 40(5):421-30. (1987) PMID 2883893
Holbrook KA, Dale BA, Witt DR, Hayden MR, Toriello HV. Arrested epidermal morphogenesis in three newborn infants with a fatal genetic disorder (restrictive dermopathy). J. Invest. Dermatol. 88(3):330-9. (1987) PMID 2434579
Suchowersky O, Hayden MR, Martin WR, Stoessl AJ, Hildebrand AM, Pate BD. Cerebral metabolism of glucose in benign hereditary chorea. Mov. Disord. 1(1):33-44. (1986) PMID 2973557
Clark CM, Hayden MR, Stoessl AJ, Martin WR. Regression model for predicting dissociations of regional cerebral glucose metabolism in individuals at risk for Huntington's disease. J. Cereb. Blood Flow Metab. 6(6):756-62. (1986) PMID 2947906
Wang HS, Greenberg CR, Hewitt J, Kalousek D, Hayden MR. Subregional assignment of the linked marker G8 (D4S10) for Huntington disease to chromosome 4p16.1-16.3. Am. J. Hum. Genet. 39(3):392-6. (1986) PMID 2945429
Bird TD, Hewitt J, Conneally PM, Hayden MR. Linkage of the G8 marker on chromosome 4 to Huntington's disease in a large American black family. N. Engl. J. Med. 315(18):1165-6. (1986) PMID 2945112
Froster-Iskenius UG, Hayden MR, Wang HS, Kalousek DK, Horsman D, Pfeiffer RA, Schottky A, Schwinger E. A family with Huntington disease and reciprocal translocation 4;5. Am. J. Hum. Genet. 38(5):759-67. (1986) PMID 2940859
Hayden MR, Martin WR, Stoessl AJ, Clark C, Hollenberg S, Adam MJ, Ammann W, Harrop R, Rogers J, Ruth T. Positron emission tomography in the early diagnosis of Huntington's disease. Neurology 36(7):888-94. (1986) PMID 2940474
Witt DR, Hayden MR, Holbrook KA, Dale BA, Baldwin VJ, Taylor GP. Restrictive dermopathy: a newly recognized autosomal recessive skin dysplasia. Am. J. Med. Genet. 24(4):631-48. (1986) PMID 2426945
Hayden MR, Nichols JL. Molecular genetic approaches to the study of the nervous system. Dev. Neurosci. 6(4-5):189-214. (1985) PMID 6083860
Pritchard PH, Bergseth M, McLeod R, Hayden MR, Frohlich J. Urinary proteins in a patient with Tangier disease. Clin. Biochem. 18(2):98-101. (1985) PMID 3926343
Wilson RD, Hayden MR. Bilateral renal agenesis in twins. Am. J. Med. Genet. 21(1):147-52, 167-9. (1985) PMID 3890542
Gusella JF, Tanzi RE, Bader PI, Phelan MC, Stevenson R, Hayden MR, Hofman KJ, Faryniarz AG, Gibbons K. Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome. Nature 318(6041):75-8. (1985) PMID 2997623
Hayden MR, Soles JA, Ward RH. Age of onset in siblings of persons with juvenile Huntington disease. Clin. Genet. 28(2):100-5. (1985) PMID 2931216
Suchowersky O, Hayden M. Down's syndrome and Alzheimer's disease. Ann. Neurol. 16(2):263. (1984) PMID 6236743
Hayden MR, Beighton P. Genetic aspects of Huntington's chorea: results of a national survey. Am. J. Med. Genet. 11(2):135-41. (1982) PMID 6461251
Hayden MR, MacGregor JM, Saffer DS, Beighton PH. The high frequency of juvenile Huntington's chorea in South Africa. J. Med. Genet. 19(2):94-7. (1982) PMID 6210776
Hayden MR, Berkowicz AL, Beighton PH, Yiptong C. Huntington's chorea on the island of Mauritius. S. Afr. Med. J. 60(26):1001-2. (1981) PMID 6460324
Beighton P, Hayden MR. Huntington's chorea. S. Afr. Med. J. 59(8):250. (1981) PMID 6451036
Hayden MR, Ehrlich R, Parker H, Ferera SJ. Social perspectives in Huntington's chorea. S. Afr. Med. J. 58(5):201-3. (1980) PMID 6447366
Hayden MR, Hopkins HC, Macrea M, Beighton PH. The origin of Huntington's chorea in the Afrikaner population of South Africa. S. Afr. Med. J. 58(5):197-200. (1980) PMID 6447365
Hayden MR, MacGregor JM, Beighton PH. The prevalence of Huntington's chorea in South Africa. S. Afr. Med. J. 58(5):193-6. (1980) PMID 6447364
Rosman MS, Lubbe WF, Hayden M, Basson N, Uys CJ. Q fever endocarditis: a report of 2 cases. S. Afr. Med. J. 53(8):296-300. (1978) PMID 653535
Hayden MR, Nelson MM. The fetal alcohol syndrome. S. Afr. Med. J. 54(14):571-4. (1978) PMID 569911
Hayden M. The fetal hydantoin syndrome. A case report. S. Afr. Med. J. 53(4):145-6. (1978) PMID 565950
Hayden MR, Beighton P. Huntington's chorea in the Cape coloured community of South Africa. S. Afr. Med. J. 52(22):886-8. (1977) PMID 146919
Hayden MR, Vinik AI, Paul M, Beighton P. Impaired prolactin release in Huntington's chorea. Evidence for dopaminergic excess. Lancet 2(8035):423-6. (1977) PMID 70642