Kelly McNagny, PhD
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Professor Department of Medical Genetics, University of British Columbia Michael Smith Foundation for Health Research Research Scholar Member of the Stem Cell Network Centre of Excellence Member of the AllerGen Network Centre for Excellence Associate Member of the Stroke Network Centre of Excellence Tel: 604-822-7824 Email:  |
Selected Publications:
Nielsen JS and McNagny KM. functions of the CD34 family. J Cell Science 121: 2683-2692, 2008
Haddon DJ, Antignano F, Hughes MR, Blanchet M-R, Zbytnuik L, Krystal G, and McNagny KM. SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. J. Immunol. 183: 228-36, 2009
Bennett JL, Blanchet M-R, Zhou L, Kubes P, and McNagny KM. Mast cells accumulate in the CNS through both local proliferation and peripheral recruitment during EAE but are dispensable for pathogenesis. J. Immunol. 182: 5507-14, 2009
Blanchet MR, Maltby S, Haddon DJ, Merkens H, Zbytnuik L and McNagny KM. CD34 Facilitates The Development of Allergic Asthma. Blood 110:2005-2012, 2007
Gournaris E, Erdman, SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM*, Khazaie K. Mast Cells are an essential component for polyp development. Proc. Nat. Acad. Science 104: 19977-19982, 2007
Nielsen JS, McCoy ML, Chellliah S, Vogl WA, Roskelley CA, and McNagny KM. The CD34-related molecule, Podocalyxin is an inducer of microvilli formation. PLoS One 2: 1-12, 2007
Doyonnas R*, Nielsen J*, Drew E, Chelliah SJ, Hara T. Miyajima A, and McNagny, KM. Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells. Blood. Plenary paper 105:4170-4178, 2005
Drew E, Merzaban J, Seo W, Ziltener HJ, and McNagny, KM. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Immunity. 22: 43-57, 2005
Somasiri A, Nielsen J, Makretsov N, Gilks CB, Huntsman D, Gelmon KA, Kershaw DB, and McNagny KM*, Roskelley C.* Overexpression of the anti-adhesin Podocalyxin is an independent predictor of breast cancer progression. Cancer Research 64: 5068-5073, 2004
Doyonnas R, Kershaw DB, Duhme C, Merkens H, Chelliah S, Graf T and McNagny KM. Anuria, omphalocele and perinatal lethality in mice lacking the CD34-related protein, Podocalyxin. J. Exp. Med 194: 13-27, 2001
McNagny KM, Sieweke M, Doderlein G, Graf T, and Nerlov C. Regulation of eosinophil-specific gene expression by a C/EBP-Ets-1 complex and GATA-1. EMBO J 17:3669-3680, 1998
McNagny KM, Pettersson I, Rossi F, Flamme I, Shevchenko A, Mann M, and Graf T. Thrombomucin, a novel cell surface protein that defines thrombocytes and multipotent hematopoietic progenitors. J. Cell Biol 138: 1395-1407, 1997
Haddon DJ, Hughes MR, Antignano F, Westaway D, Cashman NR, and McNagny KM. Expression profiling identifies PrP as a mast cell membrane protein released upon cell activation. J. Infectious Disease (200: 827-831, 2009).
Blanchet MR and McNagny KM. Stem cells, inflammation and allergy. Allergy, Asthma, and Clin Immunol. (in press, 2009).
Nielsen JS and McNagny KM. CD34 is a key regulator of hematopoietic stem cell trafficking to bone marrow and mast cell precursor trafficking in the periphery. Microcirculation 27:1-10, 2009.
Haddon DJ, Antignano F, Hughes MR, Blanchet M-R, Zbytnuik L, Krystal G, and McNagny KM. SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. J. Immunol. 183: 228-36, 2009.
Strilic B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N and Lammert E. The molecular basis of vascular lumen formation in the developing mouse aorta. Developmental Cell (in press, 2009).
Lin KBL, Tan P, Freeman SA, Lam M, McNagny KM, and Gold, MR. The Rap GTPases regulate the migration, invasiveness, and in vivo dissemination of B-cell lymphomas. Oncogene (in press, 2009).