Michael S. Kobor, PhD
| Assistant Professor |
Selected Publications:
Lu P, Lévesque N, and Kobor MS . NuA4 and SWR1-C: Two Chromatin Modifying Complexes with Overlapping Functions and Components Biochemistry and Cell Biology 87(5):799-815. (2009)
Schulze JM, Jackson J, Nakanishi S, Gardner JM, Hentrich T, Haug J, Johnston M, Jaspersen SL, Kobor MS, Shilatifard A. Linking Cell Cycle to Histone Modifications: SBF and H2B Monoubiquitination Machinery and Cell-Cycle Regulation of H3K79 Dimethylation. Mol. Cell (2009) PMID 19682934
Miller GE, Chen E, Fok AK, Walker H, Lim A, Nicholls EF, Cole S, Kobor MS. Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc. Natl. Acad. Sci. U.S.A. (2009) PMID 19617551
Kobor MS, Lorincz MC. H2A.Z and DNA methylation: irreconcilable differences. Trends Biochem. Sci. 34(4):158-61. (2009) PMID 19282182
Schulze JM, Wang AY, Kobor MS. YEATS domain proteins: a diverse family with many links to chromatin modification and transcription. Biochem. Cell Biol. 87(1):65-75. (2009) PMID 19234524
Yuen R, Avila L, Peñaherrera M, von Dadelszen P, Lefebvre L, Kobor MS, and Robinson WP . Human Placental-Specific Epipolymorphism and its Association with Adverse Pregnancy Outcomes PLoS One (2009)
Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, and Kobor MS. Asf1-like Structure of the Conserved Yaf9 YEATS Domain and Role in H2A.Z Deposition and Acetylation Proceedings of the National Academy of Sciences (2009)
Roberts TM, Kobor MS, Bastin-Shanower SA, Ii M, Horte SA, Gin JW, Emili A, Rine J, Brill SJ, Brown GW. Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol. Biol. Cell 17(1):539-48. (2006) PMID 16267268
Di Lello P, Nguyen BD, Jones TN, Potempa K, Kobor MS, Legault P, Omichinski JG. NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites. Biochemistry 44(21):7678-86. (2005) PMID 15909982
Kong SE, Kobor MS, Krogan NJ, Somesh BP, Søgaard TM, Greenblatt JF, Svejstrup JQ. Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator. J. Biol. Chem. 280(6):4299-306. (2005) PMID 15563457
Fath S, Kobor MS, Philippi A, Greenblatt J, Tschochner H. Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis. J. Biol. Chem. 279(24):25251-9. (2004) PMID 15073185
Kobor MS, Venkatasubrahmanyam S, Meneghini MD, Gin JW, Jennings JL, Link AJ, Madhani HD, Rine J. A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin. PLoS Biol. 2(5):E131. (2004) PMID 15045029
Nguyen BD, Abbott KL, Potempa K, Kobor MS, Archambault J, Greenblatt J, Legault P, Omichinski JG. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. Proc. Natl. Acad. Sci. U.S.A. 100(10):5688-93. (2003) PMID 12732728
Nguyen BD, Chen HT, Kobor MS, Greenblatt J, Legault P, Omichinski JG. Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. Biochemistry 42(6):1460-9. (2003) PMID 12578358
Hoheisel S, Kobor MS, Pierstorff E, Greenblatt J, Kane CM. Purification and assay of Saccharomyces cerevisiae phosphatase that acts on the C-terminal domain of the largest subunit of RNA polymerase II. Meth. Enzymol. (2003) PMID 14712662
Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF. RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol. Cell. Biol. 22(20):6979-92. (2002) PMID 12242279
Kobor MS, Greenblatt J. Regulation of transcription elongation by phosphorylation. Biochim. Biophys. Acta 1577(2):261-275. (2002) PMID 12213657
Cho EJ, Kobor MS, Kim M, Greenblatt J, Buratowski S. Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain. Genes Dev. 15(24):3319-29. (2001) PMID 11751637
Kobor MS, Simon LD, Omichinski J, Zhong G, Archambault J, Greenblatt J. A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae. Mol. Cell. Biol. 20(20):7438-49. (2000) PMID 11003641
Kobor MS, Archambault J, Lester W, Holstege FC, Gileadi O, Jansma DB, Jennings EG, Kouyoumdjian F, Davidson AR, Young RA, Greenblatt J. An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae. Mol. Cell 4(1):55-62. (1999) PMID 10445027
Hirst M, Kobor MS, Kuriakose N, Greenblatt J, Sadowski I. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8. Mol. Cell 3(5):673-8. (1999) PMID 10360183
Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J. An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 94(26):14300-5. (1997) PMID 9405607
Kontermann RE, Kobor M, Bautz EK. Identification of a nucleic acid-binding region within the largest subunit of Drosophila melanogaster RNA polymerase II. Protein Sci. 2(2):223-30. (1993) PMID 8443600