Elizabeth M. Simpson, PhD
 
| Professor Research Administrator: Katrina Bepple |
Selected Publications:
Aubrecht J, Goad ME, Czopik AK, Lerner CP, Johnson KA, Simpson EM, Schiestl RH. (2011) A high G418-resistant neo(R) transgenic mouse and mouse embryonic fibroblast (MEF) feeder layers for cytotoxicity and gene targeting in vivo and in vitro. Oct; 34(4):433-9. PMID 21740348
Mazarei, G., Neal, S.J., Lu, G., Simpson, E.M., and Leavitt, B.R. (2010) Expression Analysis of Novel Striatal-enriched Genes in Huntington Disease. Hum Mol Genet: 19(4):609-22. PMID 19934114
Milisavljevic, M., Hearty, T., Wong, T., Portales-Casamar, E., Simpson, E.M., and Wasserman, W.W. (2010) Laboratory Animal Management Assistant (LAMA): a LIMS for active research colonies. Mamm Genome. 21(5-6):224-30. PMID 20411264
Wong, B.K.Y., Hossain, S.M., Trinh, E., Ottmann, G.A., Budaghzadeh, S., Zheng, Q.Y., and Simpson, E.M. (2010) Hyperactivity, Startle Reactivity and Cell-proliferation Deficits are Lithium Resistant in Nr2elfrc/frc Mice. Genes, Brain and Behavior. 9(7):681-694. PMID 20497236
Portales-Casamar, E., et al., Goldowitz, D., Wasserman, W.W., Simpson, E.M. (2010) A Regulatory Toolbox of MiniPromoters to Drive Selective Expression in the Brain. Proc. Natl. Acad. Sci. U.S.A. PMID 20807748
Yang GS, Banks KG, Bonaguro RJ, Wilson G, Dreolini L, de Leeuw CN, Liu L, Swanson DJ, Goldowitz D, Holt RA, Simpson EM. (2009) Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics 93(3):196-204. PMID 18950699
Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC. (2009) Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457(7229):599-602. PMID 19078957Kumar RA, McGhee KA, Leach S, Bonaguro R, Maclean A, Aguirre-Hernandez R, Abrahams BS, Coccaro EF, Hodgins S, Turecki G, Condon A, Muir WJ, Brooks-Wilson AR, Blackwood DH, Simpson EM. (2008) Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B(6):880-9. PMID 18205168
De Leeuw CN. (2008) CMT4J: Charcot–Marie–Tooth disorder caused by mutations in FIG4. Clinical Genetics 73(4):318-319.
Oberlander TF, Bonaguro RJ, Misri S, Papsdorf M, Ross CJ, Simpson EM. (2008) Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications. Mol. Psychiatry 13(1):65-73. PMID 17519929
D'Souza CA, Chopra V, Varhol R, Xie YY, Bohacec S, Zhao Y, Lee LL, Bilenky M, Portales-Casamar E, He A, Wasserman WW, Goldowitz D, Marra MA, Holt RA, Simpson EM, Jones SJ. (2008) Identification of a set of genes showing regionally enriched expression in the mouse brain. BMC Neuroscience. PMID 18625066
Kumar RA, Leach S, Bonaguro R, Chen J, Yokom DW, Abrahams BS, Seaver L, Schwartz CE, Dobyns W, Brooks-Wilson A, Simpson EM. (2007) Mutation and evolutionary analyses identify NR2E1-candidate-regulatory mutations in humans with severe cortical malformations. Genes Brain Behav. 6(6):503-16. PMID 17054721
Kumar RA, Everman DB, Morgan CT, Slavotinek A, Schwartz CE, Simpson EM. (2007) Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes. BMC Med. Genet. PMID 17655765
Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW. (2006) Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev. Biol. 300(2):523-33. PMID 17027958
Devon RS, Orban PC, Gerrow K, Barbieri MA, Schwab C, Cao LP, Helm JR, Bissada N, Cruz-Aguado R, Davidson TL, Witmer J, Metzler M, Lam CK, Tetzlaff W, Simpson EM, McCaffery JM, El-Husseini AE, Leavitt BR, Hayden MR. (2006) Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc. Natl. Acad. Sci. U.S.A. 103(25):9595-600. PMID 16769894
Kuo BY, Chen Y, Bohacec S, Johansson O, Wasserman WW, Simpson EM. (2006) SAGE2Splice: unmapped SAGE tags reveal novel splice junctions. PLoS Comput. Biol. 2(4):e34. PMID 16683015
Christie BR, Li AM, Redila VA, Booth H, Wong BK, Eadie BD, Ernst C, Simpson EM. (2006) Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus. Neuroscience 137(3):1031-7. PMID 16289828
Siddiqui AS, Khattra J, Delaney AD, Zhao Y, Astell C, Asano J, Babakaiff R, Barber S, Beland J, Bohacec S, Brown-John M, Chand S, Charest D, Charters AM, Cullum R, Dhalla N, Featherstone R, Gerhard DS, Hoffman B, Holt RA, Hou J, Kuo BY, Lee LL, Lee S, Leung D, Ma K, Matsuo C, Mayo M, McDonald H, Prabhu AL, Pandoh P, Riggins GJ, de Algara TR, Rupert JL, Smailus D, Stott J, Tsai M, Varhol R, Vrljicak P, Wong D, Wu MK, Xie YY, Yang G, Zhang I, Hirst M, Jones SJ, Helgason CD, Simpson EM, Hoodless PA, Marra MA. (2005) A mouse atlas of gene expression: large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells. Proc. Natl. Acad. Sci. U.S.A. 102(51):18485-90. PMID 16352711
Abrahams BS, Kwok MC, Trinh E, Budaghzadeh S, Hossain SM, Simpson EM. (2005) Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1. J. Neurosci. 25(27):6263-70. PMID 16000615
Janssen PA, Nicholls TL, Kumar RA, Stefanakis H, Spidel AL, Simpson EM. (2005) Of mice and men: will the intersection of social science and genetics create new approaches for intimate partner violence? 20(1):61-71. PMID 15618562
Houde C, Banks KG, Coulombe N, Rasper D, Grimm E, Roy S, Simpson EM, Nicholson DW. (2004) Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice. J. Neurosci. 24(44):9977-84. PMID 15525783
Fedele DE, Koch P, Scheurer L, Simpson EM, Möhler H, Brüstle O, Boison D. Engineering embryonic stem cell derived glia for adenosine delivery. Neurosci. Lett. 370(2-3):160-5. (2004) PMID 15488315
Hossain SM, Wong BK, Simpson EM. (2004) The dark phase improves genetic discrimination for some high throughput mouse behavioral phenotyping. Genes Brain Behav. 3(3):167-77. PMID 15140012
Kumar RA, Chan KL, Wong AH, Little KQ, Rajcan-Separovic E, Abrahams BS, Simpson EM. (2004) Unexpected embryonic stem (ES) cell mutations represent a concern in gene targeting: lessons from "fierce" mice. Genesis 38(2):51-7. PMID 14994267
Banks KG, Johnson KA, Lerner CP, Mahaffey CL, Bronson RT, Simpson EM. (2003) Retroposon compensatory mechanism hypothesis not supported: Zfa knockout mice are fertile. Genomics 82(3):254-60. PMID 12906850
Abrahams BS, Chong AC, Nisha M, Milette D, Brewster DA, Berry ML, Muratkhodjaev F, Mai S, Rajcan-Separovic E, Simpson EM. (2003) Metaphase FISHing of transgenic mice recommended: FISH and SKY define BAC-mediated balanced translocation. Genesis 36(3):134-41. PMID 12872244
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. (2003) Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 12(13):1555-67. PMID 12812983
Abrahams BS, Mak GM, Berry ML, Palmquist DL, Saionz JR, Tay A, Tan YH, Brenner S, Simpson EM, Venkatesh B. Novel vertebrate genes and putative regulatory elements identified at kidney disease and NR2E1/fierce loci. Genomics 80(1):45-53. (2002) PMID 12079282
Simpson EM, Johnson KA, Shirley BJ, Fang GY, Bayleran JK, Lerner CP. (2002) Novel Sxr(a) ES cell line offers hope for Y chromosome gene-targeted mice. Genesis 33(2):62-6. PMID 12112873
Young KA, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, Chang B, Zheng QY, Smith RS, Bronson RT, Nelson RJ, Simpson EM. (2002) Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent. Behav. Brain Res. 132(2):145-58. PMID 11997145
Linnell ER, Lerner CP, Johnson KA, Leach CA, Ulrich TR, Rafferty WC, Simpson EM. (2001) Transgenic mice for the preparation of puromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selection. Mamm. Genome 12(2):169-71. PMID 11210188
Collins EC, Pannell R, Simpson EM, Forster A, Rabbitts TH. (2000) Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep. 1(2):127-32. PMID 11265751
Festing MF, Simpson EM, Davisson MT, Mobraaten LE. Revised nomenclature for strain 129 mice. Mamm. Genome 10(8):836. (1999) PMID 10430671
Bergstrom DE, Grieco DA, Sonti MM, Fawcett JJ, Bell-Prince C, Cram LS, Narayanswami S, Simpson EM. The mouse Y chromosome: enrichment, sizing, and cloning by bivariate flow cytometry. Genomics 48(3):304-13. (1998) PMID 9545635
George JF, Sweeney SD, Kirklin JK, Simpson EM, Goldstein DR, Thomas JM. An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow. Nat. Med. 4(3):333-5. (1998) PMID 9500608
Mutant mice and neuroscience: recommendations concerning genetic background. Banbury Conference on genetic background in mice. Neuron 19(4):755-9. (1997) PMID 9354323
Bergstrom DE, Yan H, Sonti MM, Narayanswami S, Bayleran JK, Simpson EM. An expanded collection of mouse Y chromosome RDA clones. Mamm. Genome 8(7):510-2. (1997) PMID 9195997
Mbikay M, Tadros H, Ishida N, Lerner CP, De Lamirande E, Chen A, El-Alfy M, Clermont Y, Seidah NG, Chrétien M, Gagnon C, Simpson EM. Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proc. Natl. Acad. Sci. U.S.A. 94(13):6842-6. (1997) PMID 9192653
Aubrecht J, Goad ME, Simpson EM, Schiestl RH. Expression of hygR in transgenic mice causes resistance to toxic effects of hygromycin B in vivo. J. Pharmacol. Exp. Ther. 281(2):992-7. (1997) PMID 9152410
Simpson EM, Linder CC, Sargent EE, Davisson MT, Mobraaten LE, Sharp JJ. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat. Genet. 16(1):19-27. (1997) PMID 9140391
Enerbäck S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper ME, Kozak LP. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387(6628):90-4. (1997) PMID 9139827
Mahaffey CL, Bayleran JK, Yeh GY, Lee TC, Page DC, Simpson EM. Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family. Genomics 41(1):123-7. (1997) PMID 9126493
Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6(3):303-13. (1997) PMID 9075931
Navin A, Prekeris R, Lisitsyn NA, Sonti MM, Grieco DA, Narayanswami S, Lander ES, Simpson EM. Mouse Y-specific repeats isolated by whole chromosome representational difference analysis. Genomics 36(2):349-53. (1996) PMID 8812464
Bayleran JK, Yan H, Hopper CA, Simpson EM. Frequencies of cystic fibrosis mutations in the Maine population: high proportion of unknown alleles in individuals of French-Canadian ancestry. Hum. Genet. 98(2):207-9. (1996) PMID 8698344
Mbikay M, Tadros H, Seidah NG, Simpson EM. Linkage mapping of the gene for the LIM-homeoprotein LIM3 (locus Lhx3) to mouse chromosome 2. Mamm. Genome 6(11):818-9. (1995) PMID 8597642
Johnson KA, Lerner CP, Di Lacio LC, Laird PW, Sharpe AH, Simpson EM. Transgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections. Nucleic Acids Res. 23(7):1273-5. (1995) PMID 7739908
Mbikay M, Seidah NG, Chrétien M, Simpson EM. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. Genomics 26(1):123-9. (1995) PMID 7782070
Zambrowicz BP, Findley SD, Simpson EM, Page DC, Palmiter RD. Characterization of the murine Zfy1 and Zfy2 promoters. Genomics 24(2):406-8. (1994) PMID 7698773
Zambrowicz BP, Zimmermann JW, Harendza CJ, Simpson EM, Page DC, Brinster RL, Palmiter RD. Expression of a mouse Zfy-1/lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis. Development 120(6):1549-59. (1994) PMID 8050362
Simpson EM, Page DC. An interstitial deletion in mouse Y chromosomal DNA created a transcribed Zfy fusion gene. Genomics 11(3):601-8. (1991) PMID 1774064
Page DC, Disteche CM, Simpson EM, de la Chapelle A, Andersson M, Alitalo T, Brown LG, Green P, Akots G. Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs. Genomics 7(1):37-46. (1990) PMID 1970799
Mardon G, Luoh SW, Simpson EM, Gill G, Brown LG, Page DC. Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers. Mol. Cell. Biol. 10(2):681-8. (1990) PMID 2105457
Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG. The sex-determining region of the human Y chromosome encodes a finger protein. Cell 51(6):1091-104. (1987) PMID 3690661
Himmelfarb HJ, Simpson EM, Friesen JD. Isolation and characterization of temperature-sensitive RNA polymerase II mutants of Saccharomyces cerevisiae. Mol. Cell. Biol. 7(6):2155-64. (1987) PMID 3299061
Elliott EM, Henderson G, Sarangi F, Ling V. Complete sequence of three alpha-tubulin cDNAs in Chinese hamster ovary cells: each encodes a distinct alpha-tubulin isoprotein. Mol. Cell. Biol. 6(3):906-13. (1986) PMID 3773896
Elliott EM, Sarangi F, Henderson G, Ling V. Cloning of 11 alpha-tubulin gene sequences from the genome of Chinese hamster ovary cells. Can. J. Biochem. Cell Biol. 63(6):511-8. (1985) PMID 2931165
Elliott EM, Okayama H, Sarangi F, Henderson G, Ling V. Differential expression of three alpha-tubulin genes in Chinese hamster ovary cells. Mol. Cell. Biol. 5(1):236-41. (1985) PMID 3982416
Elliott EM, Ling V. Selection and characterization of Chinese hamster ovary cell mutants resistant to melphalan (L-phenylalanine mustard). Cancer Res. 41(2):393-400. (1981) PMID 7448783
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Last updated: December 5, 2011