D.M. Juriloff, PhD

Professor
Department of Medical Genetics, University of British Columbia
c/o Life Sciences Centre
Rm. 1.364 – 2350 Health Sciences Mall
Vancouver, BC V6T 1Z3

Fax: (604) 822-5348

Email: diana.juriloff@ubc.ca

Lab web page

Research Interests: Genetics of birth defects

We focus on craniofacial defects, particularly mouse models of the common human birth defects cleft lip and palate, and anencephaly. Both are genetically complex multifactorial traits. We have mapped to various chromosomal locations the gene loci that interact to cause these birth defects, and are identifying the genes involved and the specific alteration in each of the genes or their regulatory regions. We also study the sequence of embryological events that lead to the developmental defects.

Selected Publications:

Juriloff, D.M. and Harris, M.J. Mouse models for neural tube closure defects. Human Molecular Genetics 9: 993-1000, 2000.

Juriloff, D.M., Gunn, T.G., Harris, M.J., Mah, D.G., Wu, M.K. and Dewell, S.K. Multifactorial genetics of exencephaly in SELH/Bc mice. Teratology 64:189-200, 2001.

Juriloff, D.M., Harris, M.J., Dewell, S.L. A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci. Birth Defects Research (Part A):70:509-518, 2004.

Juriloff, D.M., Harris, M.J., Mah, D.G. The open-eyelid mutation, lidgap-Gates, is an eight-exon deletion in the mouse Map3k1 gene. Genomics 85:139-142, 2005.

Juriloff, D.M., Harris, M.J., Dewell, S.L., et al. Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice. Birth Defects Research (Part A): 73:103-113, 2005

Juriloff, D.M., Harris, M.J., McMahon, A.P., Carroll, T.J., Lidral, A.C. Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Birth Defects Research (Part A),76:574-579, 2006.

Juriloff, D.M., Harris, M.J. Mouse genetic models of cleft lip with or without cleft palate. Birth Defects Research (Part A), 82:63-77, 2008