Ann M. Rose, PhD
Professor
Department of Medical Genetics
University of British Columbia
4th Floor, NCE Building
2125 East Mall
Vancouver, B.C. V6T 1Z4
Fax: (604) 822-5348
Email: ann.rose@ubc.ca
Research Interests:
The nematode Caenorhabditis elegans has many advantages as a model organism. The availability of the genomic sequence, along with powerful genetics, provides an excellent set of tools for tackling biological questions. My laboratory is investigating the organization of a gene encoding several forms of a protein protease that processes a number of proproteins, getting them "ready for work". At least four different polypeptides are formed from the gene by alternative splicing. We are characterizing where and when these endoproteases express, and the substrates that they cleave. A second gene that we are studying is involved in determining the meiotic pattern of crossover events. The molecular nature of this gene product, and how it determines the positioning of meiotic exchange is under investigation. Thirdly, we have begun an analysis of genes involved in cell cycle control, specifically those that affect kinetochore function during the anaphase to metaphase transition. Finally, we are investigating the function of a C. elegans homologue for the huntington-interacting protein, hip-1.
Selected Publications:
Jillian L. Youds, Nigel J. O’Neil and Ann M. Rose. Analysis of repair mechanisms that act on replication forks stalled by DNA secondary structure in Caenorhabditis elegans dog-1 mutants. Revisions submitted to Genetics, February 2006
O’Neil N. and Rose AM. DNA Repair (2005) WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook. 1.54.1, http:www.wormbook.org (2005).
Wicky, C, Alpi A, Passannate M, Rose A, Gartner A, Muller F. Multiple genetic pathways involving the Caenorhabditis elegans Bloom's Syndrome pathway genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line. Mol. Cell Biol. 24(11): 5106-5027 (2004).
Bosher JM, Hahn B-S, Legouis R, Sookhareena S, Gansmuller A, Chisholm A, Rose AM, Labouesse M. The C. elegans plakin locus provides resistance to mechanical stress. Journal of Cell Biology, 161(4): May 26, 757-768 (2003).
Yingzi Xue, Hanna Fares, Barth Grant, Zhai Li, Ann M. Rose, Scott G. Clark and Edward Y. Skolnik Genetic Analysis of the Myotubaularin Family of Phosphatases in Caenorhabditis elegans. Journal of Biological Chemistry: June 4, (2003).
Kitagawa R, Law E, Tang L, Rose AM. FZY-1 and its interacting protein, IFY-1 are required for proper chromosome segregation in Caenorhabditis elegans. Current Biology, 12:2118-2123 (2002).
Cheung I, Schertzer M, Rose AM, Lansdorp P. Disruption of the dog-1 gene in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nature Genetics, 31:405-409 (2002).
Kitagawa R, Law E, Tang L, Rose AM. FZY-1 and its interacting protein, IFY-1 are required for proper chromosome segregation in Caenorhabditis elegans. Current Biology, 12:2118-2123 (2002).
Long X;Spycher C;Han ZS;Rose AM;Muller F;Avruch J TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Current Biology 12: 1448-1461 (2002).
Cheung I, Schertzer M, Rose AM, Lansdorp P. Disruption of the dog-1 gene in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nature Genetics, 31:405-409 (2002).
Brinkman FSL, Blanchard JL, Cherkasov A, Greberg, H., Av-Gay Y, Brunham RC, Fernandez RC, Finlay BB, Otto SP, Ouellette BFF, Keeling PJ, Hancock REW, Rose AM, and Jones SJM. Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria and the chloroplast. Genome Research, 12:1159-67 (2002).
Roggo L, Bernard V, Kovacs AL, Rose AM, Savoy F, Zetka M, Wymann MP and Müller F. Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. EMBO Journal 21:1673-1683 (2002).