A.D. Sadovnick, PhD

Professor, Medical Genetics
G-920 Detwiller Pavilion
VCHA - UBC Hospital
2211 Wesbrook Mall
UBC Campus
Vancouver, BC V6T 2B5

Fax: (604) 822-7362
Email: sadovnik@infinet.net

Research Interests:

I am the geneticist associated with the Multiple Sclerosis and Alzheimer Clinics, Vancouver Hospital and Health Sciences Centre. My work in these Clinics has resulted in the establishment of British Columbia and Canada-wide clinical genetic/genetic epidemiological databases which are relatively unbiased with respect to genetic factors and are representative of the general population of individuals with these disorders. These databases are used for clinical genetic, genetic epidemiological and molecular genetic research. The results of the research are clinically applicable, eg. genetic and reproductive counselling as well as provide insights into the biology and natural history of these common, complex disorders.

Selected Publications:

Willer CJ, Dyment DA, Sadovnick AD, Risch NJ, Ebers GE. Twin concordance and sibling recurrence rates in multiple sclerosis. PNAS 2003 100: 12877-12882

Ebers GC, Sadovnick AD, Dyment DA, Yee IML, Willer CJ, Risch N for the Canadian Collaborative Study Group. A parent of origin effect in multiple sclerosis: observations in half siblings. Lancet 363:857-850, 2004.

Cupples AL, Farrer LA, Sadovnick AD, Relkin N, Whitehouse P, Green RC. Estimating risk curves for first-degree relatives of patients with Alzheimer's Disease: The REVEAL Study. Genet Med 6: 192-196, 2004.

Nievergelt CM, Kripke DF, Remick RA, Sadovnick AD, McElroy SL, Keck PE, Jr., Kelsoe JR Examination of the clock gene Cryptochrome 1 in bipolar disorder: Mutational analysis and absence of evidence for linkage or association. Psychiatric Genetics, 15: 45-52, 2005.

Sadovnick AD, Yee IML, Ebers GC for The Canadian Collaborative Study Group. Multiple Sclerosis and Birth Order. Lancet Neurology, Lancet Neurology (online) 2005; doi:10.1016/S1474-4422(05)70170-8 (in press, October 2005)

Waubant E, Sadovnick AD. Interferon babies. EDITORIAL. Neurology 2005; 65:788-789.