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Angela R. Brooks-Wilson, PhD

 Angela Brooks-Wilson
Associate Professor
Department of Medical Genetics, University of British Columbia
Head, Cancer Genetics
Genome Sciences Centre, BC Cancer Research Centre
Tel: 604-675-8000
Fax: 604-675-8178
Email: abrooks-wilson
Research Interests: Genetics of human cancer susceptibility and disease resistance, particularly non-Hodgkin lymphoma, healthy aging and cervical cancer. Genetic epidemiology, genotyping, single nucleotide polymorphisms.

Selected Publications:
Bashash M, Shah A, Hislop G, Brooks-Wilson A, Le N, C Bajdik. Incidence and Survival of Gastric and sophageal Cancer Diagnosed n British Columbia, Canada, during 1990-1999. Can J Gastroenerol. 2008;22(2):143-8.

Spinelli JJ, Lai AS, Krajden M, Andonov A, Gascoyn RD, Connors JM, Brooks-Wilson A, Gallagher RP. Hapaitis C vius and risk of non-Hodgkin lymphoma in British Columbia, Canada. Int J Cancer. 2008;122(3):630-3.

Kumar RA, McLean A, Leach S, Bonaguro R, McGee KA, Aguirre-Hernande R, Abrahams BS, Coccaro EF, Hodgins S, Turecki G, Condon A, Muir W, Brooks-Wilson AR, Blackwood D and Simpson EM. Initial Association of NR2E1 with Bipolar Disorde and Identification of Candidate Mutations in Bipola Disoder, Schiophrenia and Agession hough esequencing. Am J Med Genet B Neuropsychiatr Genet. 2008.

Spinelli JJ, Ng C, Weer JP, Connors JC, Gascoyne D, Lai A, Brooks-Wilson A, Le ND, Berry BR, Gallagher RP. Organochlorines and risk of non-Hodgkin lymphoma. Int J Cance. 2007;121(12):2767-75.

Sipahimalani P, Spinelli J, MacArthur A, Lai A, Connors J, Gascoyne R, Gallagher R and Brooks-Wilson AR. Common Genetic Variation in ATM Does Not Determine Susceptibility to non-Hodgkin Lymphoma. Int J Cancer. 2007;121(9):1967-75.

Montgomery SB, Griffith OL, Schuetz JM, Brooks-Wilson A and SJM Jones. A Survey of Genomic Properties for the Detection of Regulatory Polymorphisms. PLoS Comput Biol. 2007;3(6)e106: 1-11

Novik KL, Spinelli JJ, MacArthur A, Shumansky K, Sipahimalani P, Leach S, Lai A, Connors JM, Gascoyne RD, Gallagher RP, Brooks-Wilson AR. Genetic Variation in H2AFX Contributes to Risk of Lymphoma.  Cancer Epidemiol Biomarkers Prev. 2007;16(6): 1098-1106.

Halaschek-Wiener J, Brooks-Wilson A. Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeia syndrome. J Gerontol A Biol Sci Med Sci. 2007;62(1):3-8.

Bajdik CD, Abanto ZU, Spinelli JJ, Brooks-Wilson A, Gallagher RP. Identifying related cancer types based on their incidence among people with multiple cancers. Emerg Themes Epidemiol. 2006;3:17.

Rothman N, Skibola F, Wang S, Morgan G, Lan O, Smith MT, Spinelli JJ, Willett E, Sanjose SD, Cocco P, Berndt SI, Brennan P, Brooks-Wilson A, Wacholder S, Becker N, Hartge P, Zheng T, Roman E, Holly EA, Boffetta P, Armstrong B, Cozen W, Linet M, Bosch FX, Ennas MG, Holford TR, Gallagher RP, Rollinson S, Bracci PM, Cerhan JR, Whitby D, Moore PS, Leaderer B, Lai S, Spink C, Davis S, Bosch R, Scarpa A, Zhang Y, Severson RK, Yeager-Jeffery M, Chanock S, Nieters A. 2006. Genetic variation in TNF and IL and risk of non-Hodgkin lymphoma: A report from the InterLymph Consortium. Lancet Oncol. 7(1):27-38.

Halaschek-Wiener J, Khattra J, McKay S, Pouzyrev A, Stott J, Yang G, Holt R, Jones SM, Marra MA, Brooks-Wilson A, D Riddle. Analysis of Long Lived C. Elegans daf-2 Mutants Using Serial Analysis of Gene Expression. Genome Res. 2005;15(5): 603-615. (*Corresponding Author).

Bajdik CD, Kuo B, Rusaw S, Jones S and Brooks-Wilson A. CGMIM: Automated text-mining of Online Mendelian Inheritance in Man (OMIM) to identify genetically-associated cancers and candidate genes. BMC Bioinformatics. 2005;6:78.

Anglesio MS, Evdokimova V, Melnyk N, Zhang L, Fernandez CV, Grundy PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, and PHB Sorensen. Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms’ tumour versus normal kidney. Hum Mol Genet. 2004;13:2061-74.

Brooks-Wilson AR, Kaurah P, Suriano G, Leach S, Senz J, Grehan N, et al. Germline E-Cadherin Mutations in Hereditary Diffuse Gastric Cancer: Assessment of 42 New Families and Review of Genetic Screening Criteria. J Med Genet. 2004;41:508-17.

Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY, Cloutier A, Coughlin SM, Freeman D, Girn N, Griffith OL, Leach SR, Mayo M, McDonald H, Montgomery SB, Pandoh PK, Petrescu AS, Robertson AG, Schein JE, Siddiqui A, Smailus DE, Stott JM, Yang GS, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth TF, Bowness D, Czub M, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL. The Genome sequence of the SARS-associated coronavirus. Science 2003;300:1399-404.

Clee SM, Kastelein JJ, van Dam M, Marcil M, Roomp K, Zwarts KY, Collins JA, Roelants R, Tamasawa M, Stule T, Suda T, Ceska R, Boucher B, Rondeau C, DuSouich C, Brooks-Wilson A, Molhuizen HO, Frohlich J, Jr. Genest J, Hayden MR. Age and Residual Cholesterol Efflux Affect HDL Cholesterol Levels and Coronary Artery Disease in ABCA1 Heterozygotes. J. Clin. Invest. 2000;106:1205-7.

Marcil M, Brooks-Wilson A, Clee SM, Roomp K, Zhang L-H, Yu L, Collins JA, van Dam M, Molhuizen HOF, Loubster O, Ouellette BFF, Sensen CW, Fichter K, Mott S, Denis M, Boucher B, Pimstone S, Jr. Genest J, Kastelein JJ, Hayden MR. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet. 1999;354:1341-46.

Brooks-Wilson A, Marcil M, Clee SM, Zhang L-H, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HOF, Loubster O, Ouellette BFF, Fichter K, Ashbourne-Excoffon KJD, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J, Morgan K, Koop B, Pimstone S, Kastelein JJ, Jr. Genest J, Hayden MR. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nature Genetics. 1999;22:336-345.